H
Hideaki Karaki
Researcher at University of Tokyo
Publications - 257
Citations - 9296
Hideaki Karaki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Muscle contraction & Vascular smooth muscle. The author has an hindex of 50, co-authored 255 publications receiving 9152 citations.
Papers
More filters
Journal ArticleDOI
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity
H. Ishihara,Bruce L. Martin,David L. Brautigan,Hideaki Karaki,Hiroshi Ozaki,Yukio Kato,Nobuhiro Fusetani,Shugo Watabe,Koichi Hashimoto,Daisuke Uemura,David J. Hartshorne +10 more
TL;DR: The pattern of inhibition for the phosphatase in myosin B is similar to that of the type-1 enzyme, and the effects of both compounds on various phosphatases are screened.
Journal Article
Calcium Movements, Distribution, and Functions in Smooth Muscle
Hideaki Karaki,Hiroshi Ozaki,Masatoshi Hori,Minori Mitsui-Saito,Ken-ichi Amano,Ken-ichi Harada,Shigeki Miyamoto,Hiroshi Nakazawa,Kyung-Jong Won,Koichi Sato +9 more
TL;DR: Contraction of smooth muscle is regulated by the cytosolic Ca2+ level ([Ca2+]i)b, and the sensitivity of the contractile elements in response to changes in the environment surrounding the cell.
Journal ArticleDOI
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases.
John E. Eriksson,Diana M. Toivola,Jussi Meriluoto,Hideaki Karaki,Y.-G. Han,David J. Hartshorne +5 more
TL;DR: Evidence is presented to indicate that in hepatocytes the morphological changes and effects on the cytoskeleton are due to phosphatase inhibition, and the importance of the protein phosphorylation in maintenance of structural and homeostatic integrity in these cells is indicated.
Journal ArticleDOI
Calcium release in smooth muscle.
Hideaki Karaki,George B. Weiss +1 more
TL;DR: In smooth muscle, maintenance of the contractile response is due toCa2+ influx through two types of Ca2+ channel, a voltage-dependent Ca2- channel and a receptor-linked Ca2+, but a more transient contraction can be obtained by release of Ca 2+ from a cellular store, possibly the sarcoplasmic reticulum.
Journal ArticleDOI
Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats
TL;DR: Increased airway smooth muscle contractility observed in asthmatics may be related to augmented agonist‐induced, Rho‐mediated Ca2+ sensitization of myofilaments.