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Shigeru Noguchi
Researcher at National Cancer Research Institute
Publications - 8
Citations - 240
Shigeru Noguchi is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Gene & Restriction enzyme. The author has an hindex of 7, co-authored 8 publications receiving 237 citations.
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Journal ArticleDOI
Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction.
Norihiro Okada,Shigeru Noguchi,Hiroshi Kasai,N. Shindo-Okada,T. Ohgi,T. Goto,Susumu Nishimura +6 more
TL;DR: One of the bases of Q precursors, 7-(3,4-trans-4,5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine, in tRNA in vivo actually proceeds by the tRNA transglycosylase reaction.
Journal ArticleDOI
Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine.
Shigeru Noguchi,Ziro Yamaizumi,Tadaaki Ohgi,Toshio Goto,Yukinobu Nishimura,Yukinori Hirota,Susumu Nishimura +6 more
TL;DR: One of the E. coli mutants selected for deficiency of modified nucleoside Q was found to contain an analogue of Q and normal guanosine in place of Q, designated aspreQo, which was isolated on a large scale from purified tRNATyr containing preQo.
Journal ArticleDOI
Characterization of a rat tRNA gene cluster containing the genes for tRNAAsp, tRNAGly and tRNAGlu, and pseudogenes.
TL;DR: Molecular cloning and sequence analysis of a rat DNA fragment hybridized to purified tRNAAsp revealed that the genes for t RNAAspGAU(C), tRNAGlyGGA(G), and t RNAGluGAG are in a cluster on the rat chromosome.
Journal ArticleDOI
Novel mechanism of post-transcriptional modification of tRNA: insertion of base of Q precursor into tRNA by tRNA transglycosidase reaction
Norihiro Okada,Shigeru Noguchi,Hiroshi Kasai,Nobuko Shindo-Okada,Tadaaki Ohgi,Toshio Goto,Susumu Nishimura +6 more
Journal ArticleDOI
Restriction map of double-stranded DNA copy synthesized from poliovirus Sabin 1 RNA.
TL;DR: Nearly full-sized double-stranded cDNA was prepared from virion RNA of poliovirus Sabin 1 (LSc, 2ab) strain using reverse transcriptase and indicated that the restriction map obtained was consistent with the known arrangement of viral RNA fragments.