S
Shigeto Yamawaki
Researcher at Hiroshima University
Publications - 394
Citations - 13528
Shigeto Yamawaki is an academic researcher from Hiroshima University. The author has contributed to research in topics: Depression (differential diagnoses) & Receptor. The author has an hindex of 57, co-authored 385 publications receiving 12139 citations. Previous affiliations of Shigeto Yamawaki include Life Sciences Institute & University of Tokyo.
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Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops
TL;DR: Brain mechanisms for reward prediction at different time scales in a Markov decision task and graded maps of time scale within the insula and the striatum suggest differential involvement of the cortico-basal ganglia loops in reward prediction in different time scale.
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Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain.
TL;DR: The results suggest that the chronic administration of mood stabilizers may produce a neurotrophic effect mediated by the upregulation of BDNF in the rat brain.
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DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression
Manabu Fuchikami,Shigeru Morinobu,Masahiro Segawa,Yasumasa Okamoto,Shigeto Yamawaki,Norio Ozaki,Takeshi Inoue,Ichiro Kusumi,Tsukasa Koyama,Kounosuke Tsuchiyama,Takeshi Terao +10 more
TL;DR: Results indicate that classification based on the DNA methylation profiles of CpG I of the BDNF gene may be a valuable diagnostic biomarker for major depression.
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Single prolonged stress: toward an animal model of posttraumatic stress disorder
Shigeto Yamamoto,Shigeru Morinobu,Shiro Takei,Manabu Fuchikami,Aya Matsuki,Shigeto Yamawaki,Israel Liberzon +6 more
TL;DR: The enhanced consolidation and impaired extinction of fear memory found in SPS rats suggests that this model has additional value because recent studies of PTSD indicate that memory abnormalities are a central feature.
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Low-serotonin levels increase delayed reward discounting in humans
Nicolas Schweighofer,Mathieu Bertin,Kazuhiro Shishida,Yasumasa Okamoto,Saori C. Tanaka,Shigeto Yamawaki,Kenji Doya +6 more
TL;DR: The combined results of the previous and current studies suggest that serotonin may adjust the rate of delayed reward discounting via the modulation of specific loops in parallel corticobasal ganglia circuits.