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Shigeru Morinobu
Researcher at Kibi International University
Publications - 94
Citations - 4431
Shigeru Morinobu is an academic researcher from Kibi International University. The author has contributed to research in topics: Hippocampus & Brain-derived neurotrophic factor. The author has an hindex of 33, co-authored 93 publications receiving 4091 citations. Previous affiliations of Shigeru Morinobu include Hiroshima University & Life Sciences Institute.
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Journal ArticleDOI
Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain.
TL;DR: The results suggest that the chronic administration of mood stabilizers may produce a neurotrophic effect mediated by the upregulation of BDNF in the rat brain.
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DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression
Manabu Fuchikami,Shigeru Morinobu,Masahiro Segawa,Yasumasa Okamoto,Shigeto Yamawaki,Norio Ozaki,Takeshi Inoue,Ichiro Kusumi,Tsukasa Koyama,Kounosuke Tsuchiyama,Takeshi Terao +10 more
TL;DR: Results indicate that classification based on the DNA methylation profiles of CpG I of the BDNF gene may be a valuable diagnostic biomarker for major depression.
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Single prolonged stress: toward an animal model of posttraumatic stress disorder
Shigeto Yamamoto,Shigeru Morinobu,Shiro Takei,Manabu Fuchikami,Aya Matsuki,Shigeto Yamawaki,Israel Liberzon +6 more
TL;DR: The enhanced consolidation and impaired extinction of fear memory found in SPS rats suggests that this model has additional value because recent studies of PTSD indicate that memory abnormalities are a central feature.
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Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model.
Kazuhisa Kohda,Katsuya Harada,Kunio Kato,A. Hoshino,J. Motohashi,T. Yamaji,Shigeru Morinobu,N. Matsuoka,Nobumasa Kato +8 more
TL;DR: Altogether, SPS caused a number of behavioral changes similar to those described in PTSD, which marks SPS as a putative PTSD model.
Journal ArticleDOI
Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD
Shigeto Yamamoto,Shigeru Morinobu,Manabu Fuchikami,Akiko Kurata,Toshiro Kozuru,Shigeto Yamawaki +5 more
TL;DR: It is suggested that DCS, irrespective of its mechanistic involvement in the enhancement of fear extinction, may help to reverse hippocampal plasticity, and thus reverse the NMDA compensatory alterations.