Avadhesha Surolia

TL;DR: It is demonstrated that the enoyl-ACP reductase purified from P. falciparum is triclosan sensitive and the existence of the de novo fatty acid biosynthetic pathway in this parasite is established, and a key enzyme of this pathway for the development of new antimalarials is identified.

TL;DR: It is evident that glycosylation is a multifaceted post-translational modification that serves to "outfit" proteins for fold-function balance.

TL;DR: The crystal structure of jacalin with methyl-α-D-galactose reveals that each subunit has a three-fold symmetric β-prism fold made up of three four-stranded β-sheets, providing an explanation for the relative affinities of the lectin for galactose derivatives and providing insights into the structural basis of its T-antigen specificity.

TL;DR: Differential scanning calorimetry measurements on the thermal denaturation of the lectins and their carbohydrate complexes show that the Con A tetramer dissociates into monomers, while the pea and lentil lectin dimers dissociate into two submonomer fragments.

TL;DR: An extensive analysis of sequences and structures of several legume lectins shows that despite the hypervariability of their combining regions they exhibit within a significant pattern of uniformity, providing a framework for understanding the molecular basis of carbohydrate recognition by legumes lectins and a rationale for redesign of their ligand binding propensities.