S
Shing-Chuan Shen
Researcher at Taipei Medical University
Publications - 15
Citations - 736
Shing-Chuan Shen is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Nitric oxide & Caspase 3. The author has an hindex of 13, co-authored 15 publications receiving 679 citations. Previous affiliations of Shing-Chuan Shen include Taipei Medical University Hospital.
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Journal ArticleDOI
Lasers and Microdermabrasion Enhance and Control Topical Delivery of Vitamin C
TL;DR: The erbium:yttrium-aluminum-garnet (Er:YAG) laser showed the greatest enhancement of skin permeation of vitamin C among the modalities tested and the laser fluence and spot size were found to play important parts in controlling drug absorption.
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The Effect of Laser Treatment on Skin to Enhance and Control Transdermal Delivery of 5‐Fluorouracil
TL;DR: Histological changes induced by both the erbium:YAG and CO2 lasers had completely recovered within 4 days and both SC ablation and a thermal effect may contribute to the effect of the CO2 laser on skin structure.
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Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE2 activation
Wen Ta Chiu,Shing-Chuan Shen,Jyh-Ming Chow,Cheng Wei Lin,Ling Tin Shia,Yen-Chou Chen,Yen-Chou Chen +6 more
TL;DR: Data from the pharmacological studies using specific chemical inhibitors showed that activation of protein kinase C and extracellular signal-regulated kinases (ERKs) was involved in TPA-induced migration/invasion, COX-2 protein expression, and MMP-9 activation.
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Flavone inhibition of tumor growth via apoptosis in vitro and in vivo.
TL;DR: Evidence is provided to suggest that flavone is an effective agent to induce apoptosis in colorectal carcinoma cells in vitro and in vivo; activation of caspase 3, ROS production, and increasing p21 protein are involved.
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Erbium:YAG laser-mediated oligonucleotide and DNA delivery via the skin: an animal study.
TL;DR: This non-invasive, well-controlled technique of using an Er:YAG laser for gene therapy provides an efficient strategy to deliver ASOs and DNA via the skin.