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Shinichi Okudaira
Researcher at Tohoku University
Publications - 28
Citations - 2872
Shinichi Okudaira is an academic researcher from Tohoku University. The author has contributed to research in topics: Autotaxin & Lysophosphatidic acid. The author has an hindex of 21, co-authored 28 publications receiving 2619 citations. Previous affiliations of Shinichi Okudaira include University of Tokyo.
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Journal ArticleDOI
Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid
Masayuki Tanaka,Shinichi Okudaira,Yasuhiro Kishi,Ryunosuke Ohkawa,Sachiko Iseki,Masato S. Ota,Sumihare Noji,Yutaka Yatomi,Junken Aoki,Junken Aoki,Hiroyuki Arai +10 more
TL;DR: The present study revealed a previously unassigned role of ATX in stabilizing vessels through novel LPA signaling pathways, and revealed that ATX is responsible for the bulk of LPA production in serum.
Journal ArticleDOI
Two pathways for lysophosphatidic acid production.
TL;DR: It is revealed that one PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a novel LPA receptor called P2Y5.
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Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
Yasuhiro Kishi,Shinichi Okudaira,Masayuki Tanaka,Kotaro Hama,Dai Shida,Joji Kitayama,Takao Yamori,Junken Aoki,Takamitsu Fujimaki,Hiroyuki Arai +9 more
TL;DR: The results suggest that the autocrine production of LPA by cancer cell-derived ATX and exogenously supplied LPC contribute to the invasiveness of cancer cells and that LPA1, ATX, and LPC-producing enzymes are potential targets for cancer therapy, including GBM.
Journal ArticleDOI
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Hiroshi Nishimasu,Shinichi Okudaira,Kotaro Hama,Emiko Mihara,Naoshi Dohmae,Asuka Inoue,Ryuichiro Ishitani,Junichi Takagi,Junken Aoki,Osamu Nureki +9 more
TL;DR: The crystal structures of mouse ATX alone and in complex with LPAs with different acyl-chain lengths and saturations reveal that the multidomain architecture helps to maintain the structural rigidity of the lipid-binding pocket, which accommodates the respective LPA molecules in distinct conformations.
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Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C
Naoko Watanabe,Hitoshi Ikeda,Kazuhiro Nakamura,Ryunosuke Ohkawa,Yukio Kume,Junken Aoki,Kotaro Hama,Shinichi Okudaira,Masayuki Tanaka,Tomoaki Tomiya,Mikio Yanase,Kazuaki Tejima,Takako Nishikawa,Masahiro Arai,Hiroyuki Arai,Masao Omata,Kenji Fujiwara,Yutaka Yatomi +17 more
TL;DR: The serum ATX activity and plasma LPA level are increased in chronic hepatitis C in association with liver fibrosis, and may provide the first evidence showing a significant increase of both ATX and LPA in the blood under a specific disease.