S
Shinji Aki
Researcher at Otsuka Pharmaceutical
Publications - 24
Citations - 135
Shinji Aki is an academic researcher from Otsuka Pharmaceutical. The author has contributed to research in topics: Methanesulfonic acid & Alkyl. The author has an hindex of 8, co-authored 24 publications receiving 128 citations. Previous affiliations of Shinji Aki include Tokushima Bunri University.
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Journal ArticleDOI
Aminocarbonylation route to tolvaptan.
TL;DR: Pd-catalyzed aminocarbonylation between aryl bromide and NH-benzazepinone was effectively carried out to furnish the key intermediate for tolvaptan (up to 85%) in one step.
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Total synthesis of ardisiaquinone A, a potent 5-lipoxygenase inhibitor, isolated from Ardisia sieboldii, and degree of 5-lipoxygenase inhibitory activity of its derivatives.
Yoshiyasu Fukuyama,Yuuko Kiriyama,Mitsuaki Kodama,Hideyuki Iwaki,Shigeki Hosozawa,Shinji Aki,Kuniaki Matsui +6 more
TL;DR: Ardisiaquinone A (1), isolated as a potent 5-lipoxygenase inhibitor from the woods of Ardisia sieboldii, has been synthesized efficiently via a cross-coupling reaction between the yne 5 and the iodide 6 derived from the common intermediate 4.
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Naturally occurring 5-lipoxygenase inhibitors. VI. Structures of ardisiaquinones D, E, and F from Ardisia sieboldii.
Yoshiyasu Fukuyama,Yuuko Kiriyama,Mitsuaki Kodama,Hideyuki Iwaki,Shigeki Hosozawa,Shinji Aki,Kuniaki Matsui +6 more
TL;DR: New 1,4-benzoquinone derivatives, ardisiaquinones D(2), E(4), and F(5) along with the known ardisIAquinones A(1) and B(3) have been isolated from the leaves of Ardisia sieboldii and shown to be 5-lipoxygenase inhibitors.
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Facile Conversion of Arenediazonium Salts to the Corresponding Fluoroarenes Using Boron Trifluoride Diethyl Ether Complex
TL;DR: The conversion of various arenediazonium salts 1 to the corresponding fluoroarenes 2 has been achieved in good yields under mild conditions in boron trifluoride diethyl ether complex as mentioned in this paper.
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A practical synthesis of 3,4-diethoxybenzthioamide based on Friedel-Crafts reaction with potassium thiocyanate in methanesulfonic acid.
TL;DR: The synthesis of 3,4- diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel-Crafts reaction of 1,2-dieth Oxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature.