S
Shinji Asakura
Researcher at University of Wisconsin-Madison
Publications - 34
Citations - 631
Shinji Asakura is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Fibrin & Thrombin. The author has an hindex of 14, co-authored 34 publications receiving 623 citations.
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Journal ArticleDOI
Endothelial cell adhesion on polyurethanes containing covalently attached RGD-peptides.
Horng-Ban Lin,Carlos García-Echeverría,Shinji Asakura,Wen Sun,Deane F. Mosher,Stuart L. Cooper +5 more
TL;DR: These RGD-containing peptide-grafted polyurethane copolymers may be useful in providing an easily prepared cell-adhesive substrate for various biomaterial applications.
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Inhibition of cell adhesion by high molecular weight kininogen.
TL;DR: Results indicate that the cationic histidine-rich domain is critical for anti-adhesive activity and is somehow mobilized upon cleavage of HK by kallikrein.
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Single Glycosyltransferase, Core 2 β1→6-N-acetylglucosaminyltransferase, Regulates Cell Surface Sialyl-Lex Expression Level in Human Pre-B Lymphocytic Leukemia Cell Line KM3 Treated with Phorbolester
Mitsuru Nakamura,Takashi Kudo,Hisashi Narimatsu,Yusuke Furukawa,Jiro Kikuchi,Shinji Asakura,Wei Yang,Satsuki Iwase,Kiyohiko Hatake,Yasusada Miura +9 more
TL;DR: The results suggest that sLexexpression is critically regulated by a single glycosyltransferase, C2GnT, during differentiation of KM3 cells.
Journal ArticleDOI
Fibroblasts Spread on Immobilized Fibrin Monomer by Mobilizing a β1-class Integrin, Together with a Vitronectin Receptor αvβ3 on Their Surface
Shinji Asakura,Kazuki Niwa,Takako Tomozawa,Yong Ming Jin,Seiji Madoiwa,Yoichi Sakata,Takao Sakai,Hiroshi Funayama,Gilbu Soe,Fran Forgerty,Hajime Hirata,Michio Matsuda +11 more
TL;DR: The fibrin-mediated augmentation of cell spreading was inhibited not only by an antibody against human vitronectin receptor (LM 609) but also by an antibodies against the β1 subunit of integrin (mAb13), suggesting that theβ1-class integrin together with a vitronECTin receptor, αvβ3, is mobilized onto the surface of fibroblasts upon contact with the fibrIn monomer monolayer.
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Characterization of an abnormal fibrinogen Osaka V with the replacement of gamma-arginine 375 by glycine. The lack of high affinity calcium binding to D-domains and the lack of protective effect of calcium on fibrinolysis.
TL;DR: Analysis of lysyl endopeptidase digests of A alpha-, B beta-, or gamma-chains by high performance liquid chromatography and amino acid sequence analysis of relevant peptides revealed that about 50% of the gamma-chain has a replacement of gamma-arginine 375 by glycine, suggesting the normal structure of the COOH-terminal portion of the Gamma-chain including residue 375 is required for the full expression of high affinity calcium binding to D-domains