Shiqi Tu

TL;DR: It is observed that MAnorm2 clearly outperformed existing tools for differential ChIP-seq analysis, especially when the groups of samples being compared had distinct global within-group variability.

TL;DR: The methods are extensively classified by their strategy of statistical modeling and scope of application, and a decision tree is presented for choosing proper tools based on the specific dataset.

TL;DR: Current nanomedicines are comprehensively summarized through five general strategies to substantially enhance the efficacy of immunotherapy by heating the cold OC, and the challenges and perspectives of this expanding field for improved development of clinical applications are discussed.

TL;DR: This work took the human and mouse lncRNAs that were experimentally determined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically investigated the sequence features by developing a new computational pipeline for sequences composition analysis, which found PRC2-binding lnc RNAs were found to be associated with a set of distinctive and evolutionarily conserved sequence features.

TL;DR: In this paper , a review of metal organic frameworks (MOFs) based sonodynamic therapy (SDT) is provided, and various solutions adopted by MOFs to overcome the problems of SDT, including super-efficient sonosensitizer carriers, metal ion-optimized MOFs, multifunctional platforms for synergistic therapy, and MOFs as templates to prepare efficient nano-sonosensizers.