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Shireen A. Woodiga
Researcher at Nationwide Children's Hospital
Publications - 16
Citations - 669
Shireen A. Woodiga is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Sialic acid & Streptococcus oralis. The author has an hindex of 12, co-authored 16 publications receiving 546 citations. Previous affiliations of Shireen A. Woodiga include The Research Institute at Nationwide Children's Hospital & Ohio State University.
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Journal ArticleDOI
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
Guo-Yun Chen,Xi Chen,Samantha J. King,Karen A. Cavassani,Jiansong Cheng,Xincheng Zheng,Hongzhi Cao,Hai Yu,Jingyao Qu,Dexing Fang,Wei Wu,Xue-Feng Bai,Jin-Qing Liu,Shireen A. Woodiga,Chong Chen,Lei Sun,Cory M. Hogaboam,Steven L. Kunkel,Pan Zheng,Yang Liu +19 more
TL;DR: An intestinal perforation model of sepsis is used to show that microbial sialidases target the sialic acid–based recognition of CD24 by SiglecG/10 to exacerbate inflammation and supports the clinical potential of sIALidase inhibition for dampening inflammation caused by infection.
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Streptococcus pneumoniae can utilize multiple sources of hyaluronic acid for growth
Carolyn Marion,Jason M. Stewart,Mia Tazi,Amanda M. Burnaugh,Amanda M. Burnaugh,Caroline M. Linke,Shireen A. Woodiga,Samantha J. King,Samantha J. King +8 more
TL;DR: In vivo experiments support the hypothesis that S. pneumoniae utilizes hyaluronic acid as a carbon source during colonization and demonstrate that pneumococci can utilize the hyaluonic acid capsule of other bacterial species for growth, suggesting an alternative carbohydrate source for pneumococcal growth.
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Sialic acid transport contributes to pneumococcal colonization.
Carolyn Marion,Carolyn Marion,Amanda M. Burnaugh,Amanda M. Burnaugh,Shireen A. Woodiga,Samantha J. King,Samantha J. King +6 more
TL;DR: It is demonstrated that S. pneumoniae is able to use sIALic acid as a sole carbon source and that utilization of sialic acid is likely important during pneumococcal colonization.
Journal ArticleDOI
Identification of an ATPase, MsmK, which energizes multiple carbohydrate ABC transporters in Streptococcus pneumoniae
Carolyn Marion,Carolyn Marion,Andrew E. Aten,Shireen A. Woodiga,Samantha J. King,Samantha J. King +5 more
TL;DR: Data indicate that in vivo, MsmK energizes multiple carbohydrate transporters in S. pneumoniae, and demonstrates the first demonstration of a shared ATPase in a pathogenic bacterium.
Journal ArticleDOI
Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence.
Melissa Robb,Joanne K. Hobbs,Shireen A. Woodiga,Sarah Shapiro-Ward,Michael D. L. Suits,Nicholas McGregor,Harry Brumer,Hasan Yesilkaya,Samantha J. King,Alisdair B. Boraston +9 more
TL;DR: It is found that both endoD and ABCNG contribute to growth of S. pneumoniae, but that only SpGH92 and EndoD contribute to virulence, and that N-glycan processing, but not transport of the released glycan, is required for full virulence in S. tuberculosis.