M
Michael D. L. Suits
Researcher at Wilfrid Laurier University
Publications - 32
Citations - 1572
Michael D. L. Suits is an academic researcher from Wilfrid Laurier University. The author has contributed to research in topics: Heme & Hydrolase. The author has an hindex of 15, co-authored 31 publications receiving 1301 citations. Previous affiliations of Michael D. L. Suits include Queen's University & University of Victoria.
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Journal ArticleDOI
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Fiona Cuskin,Fiona Cuskin,Elisabeth C. Lowe,Max J. Temple,Yanping Zhu,Yanping Zhu,Elizabeth A. Cameron,Nicholas A. Pudlo,Nathan T. Porter,Karthik Urs,Andrew J. Thompson,Alan Cartmell,Artur Rogowski,Brian S. Hamilton,Rui Chen,Thomas J. Tolbert,Kathleen Piens,Debby Bracke,Wouter Vervecken,Z. Hakki,Gaetano Speciale,Jose L. Munōz-Munōz,Andrew T. Day,Maria J. Peña,Richard McLean,Michael D. L. Suits,Alisdair B. Boraston,Todd Atherly,Cherie J. Ziemer,Spencer J. Williams,Gideon J. Davies,D. Wade Abbott,D. Wade Abbott,Eric C. Martens,Harry J. Gilbert,Harry J. Gilbert +35 more
TL;DR: Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
Journal ArticleDOI
Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis.
TL;DR: The first crystal structures of processed Escherichia coli LptA in two crystal forms are presented, one with two molecules in the asymmetric unit and the other with eight, suggesting that head-to-tail stacking of LpsA molecules could be destabilized by the mutation, thereby potentially contributing to impair LPS transport.
Journal ArticleDOI
Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes
Wade Abbott,Orly Alber,Ed Bayer,Jean-Guy Berrin,Alisdair B. Boraston,Harry Brumer,Ryszard Brzezinski,Anthony J. Clarke,Beatrice Cobucci-Ponzano,Darrell Cockburn,Pedro M. Coutinho,Mirjam Czjzek,Bareket Dassa,Gideon J. Davies,Vincent G. H. Eijsink,Jens M. Eklöf,Alfons K. G. Felice,Elizabeth Ficko-Blean,Geoff Pincher,Thierry Fontaine,Zui Fujimoto,Kiyotaka Fujita,Shinya Fushinobu,Harry J. Gilbert,Tracey M. Gloster,Ethan D. Goddard-Borger,Ian R. Greig,Jan-Hendrik Hehemann,Glyn R. Hemsworth,Bernard Henrissat,Masafumi Hidaka,Ramon Hurtado-Guerrero,Kiyohiko Igarashi,Takuya Ishida,Štefan Janeček,Seino A. K. Jongkees,Nathalie Juge,Satoshi Kaneko,Takane Katayama,Motomitsu Kitaoka,Naotake Konno,Daniel Kracher,Anna A. Kulminskaya,Alicia Lammerts van Bueren,Sine Larsen,Junho Lee,Markus Linder,Leila LoLeggio,Roland Ludwig,Ana R. Luís,Mirko M. Maksimainen,Brian L. Mark,Richard McLean,Gurvan Michel,Cedric Montanier,Marco Moracci,Haruhide Mori,Hiroyuki Nakai,Wim Nerinckx,Takayuki Ohnuma,Richard W. Pickersgill,Kathleen Piens,Tirso Pons,Etienne Rebuffet,Peter J. Reilly,Magali Remaud-Simeon,Brian P. Rempel,Kyle Robinson,David R. Rose,Juha Rouvinen,Wataru Saburi,Yuichi Sakamoto,Mats Sandgren,Fathima Aidha Shaikh,Yuval Shoham,Franz J. St John,Jerry Ståhlberg,Michael D. L. Suits,Gerlind Sulzenbacher,Gerlind Sulzenbacher,Tomomi Sumida,Ryuichiro Suzuki,Birte Svensson,Toki Taira,Edward J. Taylor,Takashi Tonozuka,Breeanna R. Urbanowicz,Gustav Vaaje-Kolstad,Wim Van den Ende,Annabelle Varrot,Maxime Versluys,Florence Vincent,Florence Vincent,David J. Vocadlo,Warren W. Wakarchuk,Tom Wennekes,Rohan J. Williams,Spencer J. Williams,David Wilson,Stephen G. Withers,Katsuro Yaoi,Vivian L. Y. Yip,Ran Zhang +102 more
TL;DR: CAZypedia was initiated in 2007 to create a comprehensive, living encyclopedia of the carbohydrate-active enzymes (CAZymes) and associated carbohydrate-binding modules involved in the synthesis, modification and degradation of complex carbohydrates.
Journal ArticleDOI
Improving Biophysical Properties of a Bispecific Antibody Scaffold to Aid Developability: Quality by Molecular Design.
Thomas Spreter Von Kreudenstein,Eric Escobar-Carbrera,Paula I. Lario,Igor D'Angelo,Karine Brault,John F. Kelly,Yves Durocher,Jason Baardsnes,R. Jeremy Woods,Michael Hongwei Xie,Pierre-Alain Girod,Michael D. L. Suits,Martin J. Boulanger,David Kai Yuen Poon,Gordon Yiu Kon Ng,Surjit Bhimarao Dixit +15 more
TL;DR: It is demonstrated here that use of engineered Fc domains that mirror the natural system translates into an efficient and robust upstream stable cell line selection process as a first step toward a more developable therapeutic.
Journal ArticleDOI
Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont
Yanping Zhu,Michael D. L. Suits,Andrew J. Thompson,Sambhaji Chavan,Zoran Dinev,Claire Dumon,Claire Dumon,Nicola Smith,Kelley W. Moremen,Yong Xiang,Aloysius Siriwardena,Spencer J. Williams,Harry J. Gilbert,Harry J. Gilbert,Gideon J. Davies +14 more
TL;DR: It is shown that GH92 mannosidases are alpha-mannosidases that act via a single displacement mechanism to utilize host N-glycans to exploit dietary polysaccharides and host glycans as nutrients.