S
Shirley Li
Researcher at City of Hope National Medical Center
Publications - 25
Citations - 2000
Shirley Li is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: RNA & Small hairpin RNA. The author has an hindex of 14, co-authored 23 publications receiving 1931 citations. Previous affiliations of Shirley Li include Beckman Research Institute.
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Journal ArticleDOI
RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma
David DiGiusto,Amrita Krishnan,Lijing Li,Haitang Li,Shirley Li,Anitha Rao,Shu Mi,Priscilla Yam,Sherri Stinson,Michael Kalos,Joseph C. Alvarnas,Simon F. Lacey,Jiing Kuan Yee,Mingjie Li,Larry A. Couture,David Hsu,Stephen J. Forman,John J. Rossi,John A. Zaia +18 more
TL;DR: A step toward workable gene therapy is reported in the form of stable expression of a lentiviral vector encoding anti-HIV RNAs in blood stem cells transplanted into AIDS patients, and cells that survived for long periods of time in patients, although too scarce to cure or even improve their HIV infections.
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Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy
TL;DR: It is demonstrated that the anti-gp120 aptamer-siRNA chimera is specifically taken up by cells expressing HIV-1 gp120, and that the appended siRNA is processed by Dicer; this releases an anti-tat/rev siRNA which, in turn, inhibits HIV replication.
Journal ArticleDOI
Expression of small, therapeutic RNAs in human cell nuclei.
Paul D. Good,Alexandra Krikos,Shirley Li,Edouard Bertrand,N. S. Lee,Lori Giver,Andrew D. Ellington,J. A. Zaia,J. J. Rossi,David R. Engelke +9 more
TL;DR: In situ localization of the transcripts shows that both tRNA and U6 promoter transcripts give primarily punctate nuclear patterns, and that capping of transcripts is not required for nuclear retention, whereas other RNAs have little or no effect when expressed in these cassettes.
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Long-Term Inhibition of HIV-1 Infection in Primary Hematopoietic Cells by Lentiviral Vector Delivery of a Triple Combination of Anti-HIV shRNA, Anti-CCR5 Ribozyme, and a Nucleolar-Localizing TAR Decoy
Ming-Jie Li,James Kim,Shirley Li,John A. Zaia,Jiing Kuan Yee,Joseph S. Anderson,Ramesh Akkina,John J. Rossi +7 more
TL;DR: The results demonstrate that the combinatorial vector suppresses HIV replication long term in a more-than-additive fashion relative to the single shRNA or double shRNA/ribozyme or decoy combinations.
Journal ArticleDOI
Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs
Ming-Jie Li,Gerhard Bauer,Alessandro Michienzi,Jiing Kuan Yee,Nan Sook Lee,James Kim,Shirley Li,Daniela Castanotto,John A. Zaia,John J. Rossi +9 more
TL;DR: The results demonstrate that the lentiviral-based vectors can efficiently deliver single constructs as well as combinations of Pol III therapeutic expression units into primary hematopoietic cells for anti-HIV gene therapy and hold promise for stem or T-cell-based gene therapy for HIV-1 infection.