S
Shivan Chetty
Researcher at University of Cape Town
Publications - 17
Citations - 320
Shivan Chetty is an academic researcher from University of Cape Town. The author has contributed to research in topics: Fusion protein & Mycobacterium tuberculosis. The author has an hindex of 9, co-authored 16 publications receiving 238 citations. Previous affiliations of Shivan Chetty include Duke University & University of KwaZulu-Natal.
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Journal ArticleDOI
Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases.
TL;DR: Although “immunotherapy” is habitually associated with the treatment of cancer, this review accentuates the evolving role of key targeted immune interventions that are approved, as well as those in development, for various cancers and infectious diseases.
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CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases
Olusiji A. Akinrinmade,Shivan Chetty,Adebukola K. Daramola,Mukit-ul Islam,T. Thepen,Stefan Barth +5 more
TL;DR: A detailed summary of the data generated, together with the advantages and the clinical potential of CD64-based targeted therapies for the treatment of chronic inflammatory diseases is provided.
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A molecular assay for sensitive detection of pathogen-specific T-cells.
Victoria O. Kasprowicz,Victoria O. Kasprowicz,Jessica E. Mitchell,Jessica E. Mitchell,Shivan Chetty,Pamla Govender,Kuan-Hsiang Gary Huang,Helen A. Fletcher,Daniel P. Webster,Sebastian Brown,Anne Kasmar,Kerry A. Millington,Cheryl L. Day,Nompumelelo Mkhwanazi,Cheryl McClurg,Cheryl McClurg,Fundisiwe Chonco,Ajit Lalvani,Bruce D. Walker,Bruce D. Walker,Thumbi Ndung'u,Thumbi Ndung'u,Paul Klenerman +22 more
TL;DR: The authors' assay proved to be a sensitive assay for the detection of MTB-specific T cells, could be performed on whole blood samples of fingerprick (50 uL) volumes, and was not affected by HIV-mediated immunosuppression.
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Updates in the Development of ImmunoRNases for the Selective Killing of Tumor Cells
Sandra Jordaan,Olusiji A. Akinrinmade,Thomas Nachreiner,Christian Cremer,Krupa Naran,Shivan Chetty,Stefan Barth +6 more
TL;DR: Abrogating the natural interaction with the natural inhibitors by mutation has been shown to significantly enhance RNase activity, paving the way toward achieving cytolytic potency comparable to that of bacterial immunotoxins.
Journal ArticleDOI
Human Granzyme B Based Targeted Cytolytic Fusion Proteins.
Precious Hlongwane,Neelakshi Mungra,Suresh Madheswaran,Olusiji A. Akinrinmade,Shivan Chetty,Stefan Barth +5 more
TL;DR: Research involving the use of granzymes as cytolytic effectors fused to antibody fragments as selective binding domains for fusion protein-based targeted therapeutic strategies for various cancers is explored.