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Shoji Notomi
Researcher at Kyushu University
Publications - 34
Citations - 1462
Shoji Notomi is an academic researcher from Kyushu University. The author has contributed to research in topics: Visual acuity & Photoreceptor cell. The author has an hindex of 20, co-authored 34 publications receiving 1238 citations.
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Journal ArticleDOI
Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa.
Noriko Yoshida,Yasuhiro Ikeda,Shoji Notomi,Keijiro Ishikawa,Yusuke Murakami,Toshio Hisatomi,Hiroshi Enaida,Tatsuro Ishibashi +7 more
TL;DR: Sustained chronic inflammatory reaction may underlie the pathogenesis of RP, suggesting interventions for ocular inflammatory reaction as a potential treatment for patients with RP.
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Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration
Yusuke Murakami,Hidetaka Matsumoto,Miin Roh,Andrea Giani,Keiko Kataoka,Yuki Morizane,Maki Kayama,Aristomenis Thanos,Shunji Nakatake,Shoji Notomi,Toshio Hisatomi,Yasuhiro Ikeda,Tatsuro Ishibashi,Kip M. Connor,Joan W. Miller,Demetrios G. Vavvas +15 more
TL;DR: It is shown that receptor-interacting protein (RIP) kinase mediates necrosis and enhances inflammation in a mouse model of retinal degeneration induced by dsRNA, a component of drusen in AMD.
Journal ArticleDOI
Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa
Noriko Yoshida,Yasuhiro Ikeda,Shoji Notomi,Keijiro Ishikawa,Yusuke Murakami,Toshio Hisatomi,Hiroshi Enaida,Tatsuro Ishibashi +7 more
TL;DR: Sustained chronic inflammatory reaction may contribute to the pathogenesis of retinal degeneration in rd10 mice, suggesting interventions for ocular inflammatory reaction using antioxidants as a potential treatment for patients with RP.
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Astrocyte-Mediated Ischemic Tolerance
Yuri Hirayama,Yuri Ikeda-Matsuo,Shoji Notomi,Hiroshi Enaida,Hiroyuki Kinouchi,Schuichi Koizumi +5 more
TL;DR: It is shown that astrocytes play an essential role in the induction of brain ischemic tolerance, and that upregulation of P2X7 receptors in astroCytes is essential, and the results suggest that hypoxia-inducible factor-1α, a well known mediator of ischeic tolerance, is involved in P2x7 receptor-mediated ischeMIC tolerance.
Journal ArticleDOI
Dynamic Increase in Extracellular ATP Accelerates Photoreceptor Cell Apoptosis via Ligation of P2RX7 in Subretinal Hemorrhage
Shoji Notomi,Toshio Hisatomi,Yusuke Murakami,Hiroto Terasaki,Shozo Sonoda,Ryo Asato,Atsunobu Takeda,Yasuhiro Ikeda,Hiroshi Enaida,Taiji Sakamoto,Tatsuro Ishibashi +10 more
TL;DR: It is demonstrated that neovascular AMD with subretinal hemorrhage accompanies a significant increase in extracellular ATP, and that extracllular ATP initiates neurodegenerative processes through specific ligation of Purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7; P2 X7 receptor).