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Atsunobu Takeda
Researcher at Kyushu University
Publications - 71
Citations - 4466
Atsunobu Takeda is an academic researcher from Kyushu University. The author has contributed to research in topics: Medicine & Uveitis. The author has an hindex of 25, co-authored 59 publications receiving 4070 citations. Previous affiliations of Atsunobu Takeda include University of Kentucky.
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Journal ArticleDOI
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Mark E. Kleinman,Kiyoshi Yamada,Atsunobu Takeda,Vasu Chandrasekaran,Miho Nozaki,Judit Z. Baffi,Romulo Albuquerque,S. Yamasaki,M. Itaya,Yuzhen Pan,Binoy Appukuttan,Daniel Gibbs,Zhenglin Yang,Katalin Karikó,Balamurali K. Ambati,Balamurali K. Ambati,Traci A. Wilgus,Luisa A. DiPietro,Eiji Sakurai,Kang Zhang,Justine R. Smith,Ethan Will Taylor,Jayakrishna Ambati +22 more
TL;DR: It is shown that generic siRNAs might treat angiogenic disorders that affect 8% of the world’s population, and that si RNAs might induce unanticipated vascular or immune effects.
Journal ArticleDOI
Corneal avascularity is due to soluble VEGF receptor-1
Balamurali K. Ambati,Miho Nozaki,Nirbhai Singh,Atsunobu Takeda,P. Jani,Tushar Suthar,Romulo Albuquerque,Elizabeth Richter,Eiji Sakurai,Eiji Sakurai,Michael T. Newcomb,Mark E. Kleinman,Ruth B. Caldwell,Qing Lin,Yuichiro Ogura,Angela Orecchia,Don Samuelson,Dalen W. Agnew,Dalen W. Agnew,Judy St. Leger,W. Richard Green,Parameshwar J. Mahasreshti,David T. Curiel,Donna Kwan,Helene Marsh,Sakae Ikeda,Lucy J. Leiper,J. Martin Collinson,Sasha Bogdanovich,Tejvir S. Khurana,Masabumi Shibuya,Megan Baldwin,Napoleone Ferrara,Hans-Peter Gerber,Sandro De Falco,Jassir Witta,Judit Z. Baffi,B.J. Raisler,Jayakrishna Ambati +38 more
TL;DR: This paper showed that the cornea expresses soluble VEGF receptor-1 (sVEGFR-1; also known as sflt-1) and that suppression of this endogenous VEGGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice.
Journal ArticleDOI
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment
Atsunobu Takeda,Shinjiro Hamano,Atsushi Yamanaka,Toshikatsu Hanada,Tatsuro Ishibashi,Tak W. Mak,Akihiko Yoshimura,Hiroki Yoshida +7 more
TL;DR: The IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system during the initiation of Th1 differentiation.
Journal ArticleDOI
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth
Romulo Albuquerque,Takahiko Hayashi,Won Gil Cho,Mark E. Kleinman,Sami Dridi,Atsunobu Takeda,Judit Z. Baffi,Kiyoshi Yamada,Hiroki Kaneko,Martha G. Green,Joseph Chappell,Jörg Wilting,Herbert A. Weich,Satoru Yamagami,Shiro Amano,Nobuhisa Mizuki,Jonathan Steven Alexander,Martha L. Peterson,Rolf A. Brekken,Masanori Hirashima,Seema Capoor,Tomohiko Usui,Balamurali K. Ambati,Balamurali K. Ambati,Jayakrishna Ambati +24 more
TL;DR: The existence of a splice variant of the gene encoding vascular endothelial growth factor receptor-2 that encodes a secreted form of the protein, designated soluble VegFr-2 (sVegfr-2), that inhibits developmental and reparative lymphangiogenesis by blocking Vegf-c function is reported.
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WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production
Shinjiro Hamano,Kunisuke Himeno,Yoshiyuki Miyazaki,Yoshiyuki Miyazaki,Kazunari Ishii,Atsushi Yamanaka,Atsushi Yamanaka,Atsunobu Takeda,Manxin Zhang,Hajime Hisaeda,Tak W. Mak,Akihiko Yoshimura,Hiroki Yoshida,Hiroki Yoshida +13 more
TL;DR: During T. cruzi infection, WSX-1 suppresses liver injury by regulating production of proinflammatory cytokines, while controlling parasitemia by suppression of Th2 responses, demonstrating its novel role as an inhibitory regulator of cytokine production.