S
Shu-Ming Li
Researcher at University of Marburg
Publications - 246
Citations - 7868
Shu-Ming Li is an academic researcher from University of Marburg. The author has contributed to research in topics: Prenyltransferase & Indole test. The author has an hindex of 45, co-authored 223 publications receiving 6858 citations. Previous affiliations of Shu-Ming Li include University of Tübingen & University of Düsseldorf.
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Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
TL;DR: Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera Penicillium and Aspergillus of ascomycota.
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Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes
Christiane Wallwey,Shu-Ming Li +1 more
TL;DR: Properties of most structure genes have been assigned to reaction steps in the biosynthesis of ergot alkaloid biosynthesis by gene inactivation experiments or biochemical characterisation of the overproduced proteins.
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Identification of the Novobiocin Biosynthetic Gene Cluster of Streptomyces spheroides NCIB 11891
TL;DR: Heterologous expression of a key enzyme of novobiocin biosynthesis, i.e., novobocic acid synthetase, in Streptomyces lividans TK24 further confirmed the involvement of the analyzed genes in the biosynthesis of the antibiotic.
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Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.
Inge A. Unsöld,Shu-Ming Li +1 more
TL;DR: FgaPT2 is the first enzyme in the biosynthesis of ergot alkaloids to be purified and characterized in homogeneous form after heterologous overproduction and showed relatively strict substrate specificity for both tryptophan and DMAPP.
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The Fumitremorgin Gene Cluster of Aspergillus fumigatus: Identification of a Gene Encoding Brevianamide F Synthetase
TL;DR: It is concluded that the gene Afu8g00170, named ftmA, encodes the NRPS brevianamide synthetase, the precursor of a variety of fungal prenylated alkaloids with biological activity, including fumitremorgins A, B and C and tryprostatin B.