Showing papers in "Natural Product Reports in 2010"

TL;DR: The classification and chemical properties of siderophores are described, before outlining research on sidersophore biosynthesis and transport and Clinically important siderophile design and the therapeutic potential are described.

TL;DR: This review will describe only those with potentially useful antimicrobial activity, viz. with MICs in the range 0.02-10 microg mL(-1); a total of 145 compounds from 13 structural classes are discussed, and over 100 references are cited.

TL;DR: Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera Penicillium and Aspergillus of ascomycota.

TL;DR: This review provides an overview on the structural diversity, biological activities, biosynthesis and synthesis of cytochalasans (or cy tochalasins) up to the end of 2009.

TL;DR: The multi-channel quorum sensing system, the intracellular downstream processing of the signal, and the resulting response of whole populations including biofilm formation are discussed for the Vibrio genus that has been extensively investigated.

TL;DR: This review covers the recent literature on the release mechanisms for polyketides and nonribosomal peptides produced by microorganisms and focuses on the novel enzymology and mechanistic insights revealed by the biosynthetic studies of new natural products.

TL;DR: The potent biological activity of the “ancestral” gibBerellins, which has led to the independent evolution of distinct gibberellin biosynthetic pathways in plants, fungi, and bacteria, is further discussed as an archetypical example of the selective pressure driving the observed diversification of the large super-family of labdane-related diterpenoid natural products.

TL;DR: This aim is to showcase how organocatalytic reactions have overcome some of their teething problems and how they frequently offer very practical solutions to long-standing synthetic challenges.

TL;DR: This review covers recent advances in structure and function studies on the chalcone synthase (CHS) superfamily of plant type III polyketide synthases (PKSs), which catalyze iterative decarboxylative condensations of malonyl unit with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important plant secondary metabolites.

TL;DR: The myxobacteria, long a source of fascination due to their sophisticated, social lifestyles, are now increasingly recognized as multi-producers of promising natural products.

TL;DR: This review provides an overview of the synthetic chemistry that has been utilised to prepare natural products containing a pyrrolic ring.

TL;DR: Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase, in order to find new antibiotics with activity against Gram-negative bacteria.

TL;DR: The organization of the fungal epigenome is summarized and strategies for manipulating chromatin-related targets are presented.

TL;DR: This review surveys the natural products described from entomopathogenic Hypocrealean fungi, including their structures, biological activities, potential utilities in medicine, roles inEntomopathogenesis, and known or predicted biosynthetic pathways.

TL;DR: This review discusses the isolation, structural elucidation, structural classification, biological activities, semi-synthesis and total syntheses of Stemona alkaloids from 1999 to August 2009.

TL;DR: In vitro studies of so-called class II metallothioneins from a variety of phyla are focused on, highlighting the diversity of metallothsioneins in terms of structure, biological functions, and molecular functions such as metal ion specificity, thermodynamic stabilities, and kinetic reactivity.

TL;DR: This review surveys possible approaches to estimation of these dissociation constants and pinpoints the various problems associated with each approach.

TL;DR: A summary of the so far known structures of the 4-Hydroxy-2-pyridone alkaloids, overview the different activities of the compounds and disclose the synthetic attempts since 1982 are given.

TL;DR: This comprehensive review summarizes the enormous potential for discovery of new natural products with medicinal value from among the phylum Arthropoda and describes examples from the literature of insect-derived substances with medicinally relevant biological properties.

TL;DR: This review covers the synthetic aspects of various naturally occurring phloroglucinols, describing syntheses of 42 compounds and citing 137 references.

TL;DR: In this review, the roles of flavones in various metabolic and systemic disease models are discussed and their structure–activity relationships have generated interest among medicinal chemists.

TL;DR: This review summarises the chemistry of low molecular weight polyphenols isolated and characterised from black tea, discussing both structures identified and mechanisms of their likely formation.

TL;DR: Some recent applications of the new NMR methodology to the area of natural products discovery are discussed, along with a perspective of practical limitations and potential future applications in new areas.

TL;DR: This review covers the highlights of combinatorial biosynthesis using polyketide-modifying enzymes such as oxidoreductases, group transferases, halogenases, cyclases and deoxysugar biosynthesis enzymes, focusing on those from actinomycetes.

TL;DR: This review is devoted to moenomycins, the only known group of antibiotics that directly inhibit bacterial peptidoglycan glycosytransferases, portraying a complete picture of the chemistry and biology of these fascinating natural products.

TL;DR: A review of the isolation, biological activity and synthesis of natural products containing a benzannulated spiroketal moiety is provided.

TL;DR: Crystal structures support the interpretation of kinase selectivity profiles of staurosporine and its analogues, including midostaurin (PKC412), for which a co-crystal structure is not yet available.

TL;DR: This review summarises the different families of bacterial metal-sensing transcriptional regulators and discusses current knowledge regarding the mechanisms of metal-regulated gene expression and the structural features of sensory metal-binding sites focusing on the ArsR-SmtB family.

TL;DR: This review summarizes the research on the isolation, structure elucidation, biological activities, biosynthesis, and chemical synthesis of the spirodioxynaphthalenes published over the last 20 years.

TL;DR: This review discusses the enzymatic basis of the different cyclization strategies used by bacteria and fungi in the biosynthesis of aromatic polyketides.