Journal ArticleDOI
Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
TLDR
Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera Penicillium and Aspergillus of ascomycota.About:
This article is published in Natural Product Reports.The article was published on 2010-01-01. It has received 380 citations till now. The article focuses on the topics: Indole test & Brevianamide F.read more
Citations
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Biosynthesis of fungal meroterpenoids
Yudai Matsuda,Ikuro Abe +1 more
TL;DR: This review summarizes the molecular bases for their biosyntheses, which were recently elucidated with modern techniques, and also discusses the plausible biosynthetic pathways of other related natural products lacking genetic information.
Journal ArticleDOI
Synthetic approaches to 3-(2-nitroalkyl) indoles and their use to access tryptamines and related bioactive compounds.
Journal ArticleDOI
Molecular diversity of spirooxindoles. Synthesis and biological activity
TL;DR: This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Journal ArticleDOI
Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes
Christiane Wallwey,Shu-Ming Li +1 more
TL;DR: Properties of most structure genes have been assigned to reaction steps in the biosynthesis of ergot alkaloid biosynthesis by gene inactivation experiments or biochemical characterisation of the overproduced proteins.
Journal ArticleDOI
Marine Indole Alkaloids
Natalie Netz,Till Opatz +1 more
TL;DR: Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors.
References
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Journal ArticleDOI
Endophytes: a rich source of functional metabolites.
Ren-Xiang Tan,W. X. Zou +1 more
Journal Article
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.
John F. Allen,Arnold van Loevezijn,Jeany M Lakhai,Martin van der Valk,Olaf van Tellingen,Glen Reid,Jan H.M. Schellens,Gerrit-Jan Koomen,Alfred H. Schinkel +8 more
TL;DR: A new tetracyclic analogue of FTC, Ko143, is evaluated as a practical inhibitor of BCRP, proving highly active for increasing the intracellular drug accumulation and reversing Bcrp1/BCRP-mediated multidrug resistance.
Journal ArticleDOI
Toxins of cyanobacteria
TL;DR: Toxicity data on cyanotoxins are rather scarce, and a majority of toxicity data are known to be of microcystin-LR, while for nodularins, data from a few animal studies are available.
Journal ArticleDOI
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
Tomomi Kawasaki,Kazuhiro Higuchi +1 more
TL;DR: This review covers the literature on simple indole alkaloid and those with a nonrearranged monoterpenoid unit and newly isolated alkaloids, structure determinations, total syntheses and biological activities.
Journal Article
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.
TL;DR: It is reported that FTC almost completely reverses resistance mediated by BCRP in vitro and is a pharmacological probe for the expression and molecular action of this transporter.
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Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.
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