Showing papers in "Natural Product Reports in 2011"

TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.

TL;DR: The review will discuss the enzymes for lignin breakdown in fungi and bacteria, and the catabolic pathways for breakdown of the β-aryl ether, biphenyl and other components of lign in bacteria and fungi, and includes a bioinformatic analysis of the occurrence of known lignIn-degradation pathways in Gram-positive and Gram-negative bacteria.

TL;DR: An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.

TL;DR: How curcumin directly targets signaling molecules, as well as the different forces that bind theCurcumin-protein complex and how this interaction affects the biological properties of proteins are focused on.

TL;DR: This is a review of anticancer agents isolated from endophytic fungi from 1990–2010, based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines.

TL;DR: This review focuses on plant Carotenoids, but it also includes progress made on microbial and animal carotenoid metabolism to better understand the functions and the evolution of these structurally diverse compounds with a common backbone.

TL;DR: This review is peppered with approaches that may expand the screening of streptomycetes for new antibiotics by awakening expression of cryptic antibiotic biosynthetic genes.

TL;DR: This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease and discusses more than 180 compounds and summarizes 400 references.

TL;DR: The aim of this review is to illustrate the recent advances in the isolation and analysis of ginseng, and to highlight new applications and challenges.

TL;DR: There is also growing evidence that VOCs are endowed with a range of biological activities in mammals, and that they represent a substantially under-exploited and still largely untapped source of novel drugs and drug leads.

TL;DR: This review describes applications of quantum chemical calculations in the field of terPene biosynthesis, with a focus on insights into the mechanisms of terpene-forming carbocation rearrangements arising from theoretical studies.

TL;DR: This review provides a comprehensive summary of the structural classification and distribution of these new compounds of naturally occurring withanolides.

TL;DR: The large diversity of high-yielding and chemoselective reactions that can be achieved, even for highly functionalized molecules, is summarized, demonstrating that hypervalent iodine reagents have become an essential tool in synthetic organic chemistry.

TL;DR: This review will focus on the biological activity of some of the best-studied examples of saponins, on the relationship between structure and function, and on prospects for synthesis of ‘‘designer’’ saponin compounds.

TL;DR: The in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases are covered.

TL;DR: This review covers the influence of Glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to glyco(randomization/diversification) schemes, approaches to the synthesis of required substrates and specific examples of glycorandomized libraries utilizing both wild-type and engineered enzymes.

TL;DR: A review of the known types of propolis, propolis constituents, evaluation of the biological activities of resin constituents, and determination of plant resin sources is presented in this article, with a focus on plant sources.

TL;DR: In this review, antifouling metabolites of marine bacteria and fungi, seaweeds, aquatic plants, and marine invertebrates are described and those inhibiting bacterial quorum sensing and larval settlement are described.

TL;DR: Properties of most structure genes have been assigned to reaction steps in the biosynthesis of ergot alkaloid biosynthesis by gene inactivation experiments or biochemical characterisation of the overproduced proteins.

TL;DR: This review summarizes the current knowledge on the mode of action and structure of defensins from different kingdoms, with specific emphasis on their interaction with microbial lipid receptors.

TL;DR: This Highlight provides a comprehensive and up-to-date commentary on β-glucans, their chemistry, physico-chemistry, functional role in immunological responses, and possible applications as therapeutic tools.

TL;DR: This review focuses on the phytoalexins produced by cruciferous plants reported to date, with particular emphasis on their chemical synthesis, biosynthesis, metabolism by plant fungal pathogens and biological activities.

TL;DR: This Viewpoint addresses the trade-off between endophyte discovery and viable industrial application.

TL;DR: The biosynthesis, total syntheses, and antitumor activities of tanshinones,especially neo-tanshinlactone and its analogs are discussed.

TL;DR: This review surveys advances in this family of marine alkaloids with a focus on the structural diversity, biosynthetic hypotheses with increasing, but still rare, verifying experimental studies, asymmetric syntheses, and biological studies of this stimulating and exciting alkaloid family.

TL;DR: The current knowledge of volatile halogenated compounds from algae is discussed, with a focus on biosynthesis, algal physiology and chemical ecology, and geochemical aspects arising from the release of halogenate natural products from micro- and macroalgae.

TL;DR: This review summarizes both new bufadienolides and those obtained from new sources, together with data regarding the antitumor activity of bufADienolide derivatives, from 1998 to July 2010.

TL;DR: In this paper, the authors detail the motivations, experimental approaches, and growing list of successful cases associated with the heterologous production of complex natural products and present a review of the successful cases.

TL;DR: The sorbicillinoids are a family of hexaketide metabolites that have been isolated from a variety of fungal sources, collected from both marine and terrestrial sources and has led to controversy surrounding the biosynthetic pathway responsible for the natural production of these compounds.

TL;DR: This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group.