Shuhua Yue

TL;DR: Biochemical study showed that cholesteryl ester accumulation was a consequence of loss of tumor suppressor PTEN and subsequent activation of PI3K/AKT pathway in prostate cancer cells, and open opportunities for diagnosing and treating prostate cancer by targeting the altered cholesterol metabolism.

TL;DR: In this article, the authors performed quantitative analysis of lipogenesis at single-cell level in human patient cancerous tissues and revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases.

TL;DR: The broad applications of CARS microscopy to studies of lipid biology in cell cultures, tissue biopsies, and model organisms are reviewed and recent technical advances, limitations, and perspectives are discussed.

TL;DR: This article reviews the various approaches developed for realization of multimodal NLO imaging as well as developments of new NLO modalities on a CARS microscope to applications to various aspects of biological and biomedical research.

TL;DR: It is shown that piceatannol inhibits adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner at noncytotoxic concentrations and highlights IR and its downstream insulin signaling as novel targets for pice atannol in the early phase of adipogenesis.