Bing Song

TL;DR: Biochemical study showed that cholesteryl ester accumulation was a consequence of loss of tumor suppressor PTEN and subsequent activation of PI3K/AKT pathway in prostate cancer cells, and open opportunities for diagnosing and treating prostate cancer by targeting the altered cholesterol metabolism.

TL;DR: In this article, the authors performed quantitative analysis of lipogenesis at single-cell level in human patient cancerous tissues and revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases.

TL;DR: In this paper, an aberrant accumulation of cholesteryl ester was found in human pancreatic cancer specimens and cell lines, mediated by acyl-CoA cholesterol acyltransferase-1 (ACAT-1) enzyme.

TL;DR: Abrogation of cholesterol esterification, either by an ACAT-1 inhibitor or by shRNA knockdown, significantly suppressed tumor growth and metastasis in an orthotopic mouse model of pancreatic cancer.

TL;DR: It is shown that G2 and S‐phase‐expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of G TSE1 at Ser 435 promotes its nuclear localization, and thus shuttles p53 out of the nucleus to lead to its degradation during the recovery.