S
Shuji Takada
Researcher at University of Cambridge
Publications - 9
Citations - 1420
Shuji Takada is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genomic imprinting & Gene. The author has an hindex of 8, co-authored 9 publications receiving 1349 citations. Previous affiliations of Shuji Takada include University of Queensland.
Papers
More filters
Journal ArticleDOI
Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12
Shau-Ping Lin,Neil A. Youngson,Shuji Takada,Shuji Takada,Hervé Seitz,Wolf Reik,Martina Paulsen,Martina Paulsen,Jérôme Cavaillé,Anne C. Ferguson-Smith +9 more
TL;DR: It is shown that deletion of the IG-DMR from the maternally inherited chromosome causes bidirectional loss of imprinting of all genes in the 1-Mb cluster and indicates that the two parental chromosomes control allele-specific gene expression differently.
Journal ArticleDOI
Epigenetic analysis of the Dlk1–Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2–H19
Shuji Takada,Martina Paulsen,Maxine Tevendale,Chen-En Tsai,Gavin Kelsey,Bruce M. Cattanach,Anne C. Ferguson-Smith +6 more
TL;DR: A detailed methylation analysis is described of the Dlk1-Gtl2 domain, a reciprocally imprinted genes located 80 kb apart on mouse chromosome 12, which has both unique and common features compared to those identified in the Igf2-H19 domain.
Journal ArticleDOI
Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.
Shuji Takada,Maxine Tevendale,J. Baker,Pantelis Georgiades,Elizabeth A. Campbell,Tom C. Freeman,Martin H. Johnson,Martina Paulsen,Anne C. Ferguson-Smith +8 more
TL;DR: Gtl2 is expressed from the maternal allele and methylated at the 5' end of the silent paternal allele and a reciprocally imprinted gene, Delta-like (Dlk), with homology to genes involved in the Notch signalling pathway was identified 80kb upstream of Gtl2.
Journal ArticleDOI
Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.
Martina Paulsen,Shuji Takada,Neil A. Youngson,Mehdi Benchaib,Carole Charlier,Karin Segers,Michel Georges,Anne C. Ferguson-Smith +7 more
TL;DR: Comparative genomic examination of the Dlk1-Gtl2 domain indicates that although there are similarities, other features are very different, including the location of conserved CTCF-binding sites, and the level of conservation at regulatory regions.
Journal ArticleDOI
Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo.
TL;DR: It is demonstrated that disruption of the imprinting status of Dio3 results in abnormal thyroid hormone levels and may contribute to the phenotypic abnormalities in UPD12 mice and UPD14 humans.