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Elizabeth A. Campbell
Researcher at Rockefeller University
Publications - 103
Citations - 8914
Elizabeth A. Campbell is an academic researcher from Rockefeller University. The author has contributed to research in topics: RNA polymerase & Transcription (biology). The author has an hindex of 39, co-authored 91 publications receiving 7538 citations. Previous affiliations of Elizabeth A. Campbell include Wellcome Trust.
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Journal ArticleDOI
Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
Elizabeth A. Campbell,Nataliya Korzheva,Arkady Mustaev,Katsuhiko S. Murakami,Satish K. Nair,Alex Goldfarb,Seth A. Darst +6 more
TL;DR: The crystal structure of Thermus aquaticus core RNAP complexed with Rif explains the effects of Rif on RNAP function and indicates that the inhibitor acts by directly blocking the path of the elongating RNA when the transcript becomes 2 to 3 nt in length.
Journal ArticleDOI
Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution
Gongyi Zhang,Elizabeth A. Campbell,Leonid Minakhin,Catherine Richter,Konstantin Severinov,Seth A. Darst +5 more
TL;DR: The X-ray crystal structure of Thermus aquaticus core RNA polymerase reveals a "crab claw"-shaped molecule with a 27 A wide internal channel that places key functional sites, defined by mutational and cross-linking analysis, on the inner walls of the channel in close proximity to the active center Mg2+.
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Structural Basis of Transcription Initiation: An RNA Polymerase Holoenzyme-DNA Complex
TL;DR: The crystal structure of Thermus aquaticus RNA polymerase holoenzyme (α2ββ′ωσA) complexed with a fork-junction promoter DNA fragment has been determined by fitting high-resolution x-ray structures of individual components into a 6.5-angstrom resolution map.
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Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice
Toby G Bush,Tor C. Savidge,Tor C. Savidge,Tom C. Freeman,Hilary Cox,Elizabeth A. Campbell,Lennart Mucke,Martin H. Johnson,Michael V. Sofroniew,Michael V. Sofroniew +9 more
TL;DR: It is suggested that enteric glia play an essential role in maintaining the integrity of the bowel and suggest that their loss or dysfunction may contribute to the cellular mechanisms of inflammatory bowel disease.
Journal ArticleDOI
Structure of the Bacterial RNA Polymerase Promoter Specificity σ Subunit
Elizabeth A. Campbell,Oriana Muzzin,Mark Chlenov,Jing L. Sun,C.Anders Olson,Oren Weinman,Michelle Trester-Zedlitz,Seth A. Darst +7 more
TL;DR: Proteolysis of Thermus aquaticus σ A, which occurred in situ during crystallization, reveals three domains, σ 2 , σ 3 , and σ 4 , connected by flexible linkers, and genetic studies correctly predicted that a helix-turn-helix motif in ρ 4 recognizes the −35 element but not the details of the protein-DNA interactions.