Sibylle Tluk

TL;DR: C‐ class ODN may represent new therapeutic drugs that combine the effects of A‐ and B‐Class ODN for broad applications in infectious disease or cancer therapy, and in vivo studies demonstrate that C‐ Class ODN are very potent Th1adjuvants.

TL;DR: It is shown that specific, highly conserved RNA sequences within snRNPs can stimulate Toll-like receptors (TLRs) 7 and 8 as well as activate innate immune cells, such as plasmacytoid dendritic cells (pDCs), which respond by secreting high levels of type I IFN.

TL;DR: An unexpected plasticity in the ligand specificities of TLR7 and TLR8 is demonstrated, and a novel sequence‐selective interaction between these receptors and synthetic phosphorothioate ODN is suggested.

TL;DR: It appears possible that the presence of highly conserved untranslated terminal regions in the viral genome fulfilling fundamental functions for the viral replication may enable the host to induce directed innate immune defense mechanisms, by allowing pathogen detection through essential RNA regions that the virus cannot readily mutate.

TL;DR: It is shown that even a simple natural modification such as a single 2'-O-methylation at different nucleotide positions throughout a sequence derived from a self-RNA strongly interferes with TLR-mediated effects.