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Stefan Bauer
Researcher at University of Marburg
Publications - 151
Citations - 24529
Stefan Bauer is an academic researcher from University of Marburg. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 57, co-authored 141 publications receiving 23272 citations. Previous affiliations of Stefan Bauer include Technische Universität München & University of Mainz.
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Journal ArticleDOI
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten J. Kirschning,Shizuo Akira,Grayson B. Lipford,Hermann Wagner,Stefan Bauer +8 more
TL;DR: It is shown that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus–1 (HIV-1) stimulate dendritic cells and macrophages to secrete interferon-α and proinflammatory, as well as regulatory, cytokines, and these data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8.
Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
TL;DR: An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.
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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
Stefan Bauer,Carsten J. Kirschning,Hans Häcker,Vanessa Redecke,Susanne Hausmann,Shizuo Akira,Hermann Wagner,Grayson B. Lipford +7 more
TL;DR: It is shown that human TLR9 expression in human immune cells correlates with responsiveness to bacterial deoxycytidylate-phosphate-deoxyguanylate (CpG)-DNA, and data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating Cpg-DNA.
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Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.
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An activating immunoreceptor complex formed by NKG2D and DAP10.
Jun Wu,Yaoli Song,Alexander B. H. Bakker,Stefan Bauer,Thomas Spies,Lewis L. Lanier,Joseph H. Phillips +6 more
TL;DR: In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA.