S
Silja Raschke
Researcher at University of Düsseldorf
Publications - 16
Citations - 1488
Silja Raschke is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Myokine & FNDC5. The author has an hindex of 10, co-authored 16 publications receiving 1279 citations.
Papers
More filters
Journal ArticleDOI
Evidence against a beneficial effect of irisin in humans
Silja Raschke,Manuela Elsen,Hans Gassenhuber,Mark Sommerfeld,Uwe Schwahn,Barbara Brockmann,Raphael Jung,Ulrik Wisløff,Arnt Erik Tjønna,Truls Raastad,Jostein Hallén,Frode Norheim,Christian A. Drevon,Tania Romacho,Kristin Eckardt,Juergen Eckel +15 more
TL;DR: It is rather unlikely that the beneficial effect of irisin observed in mice can be translated to humans, according to analyses of genomic DNA, mRNA and expressed sequence tags.
Journal ArticleDOI
Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise
Silja Raschke,Jürgen Eckel +1 more
TL;DR: This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1 and tries to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand.
Journal ArticleDOI
Myokines in insulin resistance and type 2 diabetes.
TL;DR: The most recent findings on the role of myokines in the regulation of substrate metabolism and insulin sensitivity are summarized and a critical assessment of irisin and other myokine regarding their potential as therapeutic targets are provided.
Journal ArticleDOI
Identification and Validation of Novel Contraction-Regulated Myokines Released from Primary Human Skeletal Muscle Cells
TL;DR: It is revealed that both factors, DPP4 and PEDF, are secreted by primary human myotubes, and the regulation and release of two selected myokines, namely pigment epithelium derived factor and dipeptidyl peptidase 4, are validated.
Journal ArticleDOI
BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells.
Manuela Elsen,Silja Raschke,Norbert Tennagels,Uwe Schwahn,Tomas Jelenik,Michael Roden,Tania Romacho,Juergen Eckel +7 more
TL;DR: It is shown for the first time that BMP4 has similar effects on white-to-brown transition as BMP7 in the human cell model, indicating that the roles of BMP5 and BMP6 in adipogenesis cannot always be extrapolated from murine to human cell models.