S
Silke Appel-Cresswell
Researcher at University of British Columbia
Publications - 41
Citations - 2132
Silke Appel-Cresswell is an academic researcher from University of British Columbia. The author has contributed to research in topics: Parkinson's disease & Medicine. The author has an hindex of 15, co-authored 37 publications receiving 1528 citations. Previous affiliations of Silke Appel-Cresswell include University of Manitoba.
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Journal ArticleDOI
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
Silke Appel-Cresswell,Carles Vilariño-Güell,Mary Encarnacion,Holly E. Sherman,Irene Yu,Brinda Shah,David W Weir,Christina Thompson,Chelsea Szu-Tu,Joanne Trinh,Jan O. Aasly,Alex Rajput,Ali H. Rajput,A. Jon Stoessl,Matthew J. Farrer +14 more
TL;DR: Three missense mutations in SNCA, the gene encoding alpha‐synuclein, as well as genomic multiplications have been identified as causes for autosomal‐dominantly inherited Parkinsonism.
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The gut microbiome in human neurological disease: A review.
TL;DR: This review provides an overview of the recent advances in microbiome research in relation to neuro(auto)immune and neurodegenerative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica spectrum disorders, Parkinson disease, Alzheimer disease, Huntington disease, and amyotrophic lateral sclerosis.
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DNAJC13 mutations in Parkinson disease
Carles Vilariño-Güell,Alex Rajput,Austen J. Milnerwood,Brinda Shah,Chelsea Szu-Tu,Joanne Trinh,Irene Yu,Mary Encarnacion,Lise N. Munsie,Lucia Tapia,Emil K. Gustavsson,Patrick Chou,Igor Tatarnikov,Daniel M. Evans,Frederick T. Pishotta,Mattia Volta,Dayne Beccano-Kelly,Christina Thompson,Michelle K. Lin,Holly E. Sherman,Heather Han,Bruce L. Guenther,Wyeth W. Wasserman,Virginie Bernard,Colin J. D. Ross,Silke Appel-Cresswell,A. Jon Stoessl,Christopher A. Robinson,Dennis W. Dickson,Owen A. Ross,Zbigniew K. Wszolek,Jan O. Aasly,Ruey-Meei Wu,Fayçal Hentati,Rachel A. Gibson,Peter S. McPherson,Martine Girard,Michele L. Rajput,Ali H. Rajput,Matthew J. Farrer +39 more
TL;DR: A temporal and functional ecology is emerging that connects synaptic exo- and endocytosis, vesicular trafficking, endosomal recycling and the endo-lysosomal degradative pathway that is genetically linked to the phenotypic spectrum of parkinsonism associated with Lewy body pathology.
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Microbiota Composition and Metabolism Are Associated With Gut Function in Parkinson's Disease.
Mihai Cirstea,Adam C. Yu,Ella Golz,Kristen Sundvick,Daniel Kliger,Nina Radisavljevic,Liam H. Foulger,Melissa Mackenzie,Tau Huan,B. Brett Finlay,Silke Appel-Cresswell +10 more
TL;DR: Assessment of associations between microbiota composition, stool consistency, constipation, and systemic microbial metabolites in Parkinson's disease helps to better understand how intestinal microbes contribute to gastrointestinal disturbances commonly observed in patients.
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Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial
Ronald B. Postuma,Julius B. M. Anang,Amélie Pelletier,Lawrence Joseph,Mariana Moscovich,David Grimes,Sarah Furtado,Renato P. Munhoz,Silke Appel-Cresswell,Adriana Moro,Andrew Borys,Douglas E. Hobson,Anthony E. Lang +12 more
TL;DR: This study provides Class I evidence that for patients with PD, caffeine does not significantly improve motor manifestations, and Epidemiologic links between caffeine and lower PD risk do not appear to be explained by symptomatic effects.