R
Rachel A. Gibson
Researcher at GlaxoSmithKline
Publications - 70
Citations - 7444
Rachel A. Gibson is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Fanconi anemia & Genome-wide association study. The author has an hindex of 37, co-authored 67 publications receiving 7096 citations. Previous affiliations of Rachel A. Gibson include Research Triangle Park & GlaxoSmithKline Pharmaceuticals Ltd.
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Journal ArticleDOI
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Philip L. De Jager,Philip L. De Jager,Xiaoming Jia,Joanne Wang,Paul I.W. de Bakker,Linda Ottoboni,Linda Ottoboni,Neelum T. Aggarwal,Laura Piccio,Soumya Raychaudhuri,Dong Tran,Cristin Aubin,Rebeccah Briskin,Susan Romano,Sergio E. Baranzini,Jacob L. McCauley,Margaret A. Pericak-Vance,Jonathan L. Haines,Rachel A. Gibson,Yvonne Naeglin,Bernard M. J. Uitdehaag,Paul M. Matthews,Ludwig Kappos,Chris H. Polman,Wendy L. McArdle,David P. Strachan,Denis A. Evans,Anne H. Cross,Mark J. Daly,Alastair Compston,Stephen Sawcer,Howard L. Weiner,Stephen L. Hauser,David A. Hafler,David A. Hafler,Jorge R. Oksenberg +35 more
TL;DR: It is reported that the susceptibility allele near IRF8, which encodes a transcription factor known to function in type I Interferon signaling, is associated with higher mRNA expression of interferon-response pathway genes in subjects with MS.
Journal ArticleDOI
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
Hao Li,Sally Wetten,Li Li,Pamela L. St. Jean,Ruchi Upmanyu,Linda Surh,David A. Hosford,Michael R. Barnes,James David Briley,Michael Borrie,Natalie Coletta,Richard Delisle,Daniella Dhalla,Margaret G. Ehm,Howard Feldman,Luis Fornazzari,Serge Gauthier,Neil Goodgame,Danilo Guzman,Sandra Hammond,Paul Hollingworth,Ging-Yuek Robin Hsiung,Joan Johnson,Devon D. Kelly,Ron Keren,Andrew Kertesz,Karen S. King,Simon Lovestone,Inge Loy-English,Paul M. Matthews,Michael John Owen,Mary Plumpton,William Pryse-Phillips,Rab K. Prinjha,Jill C. Richardson,Ann M. Saunders,Andrew J. Slater,Peter St George-Hyslop,Sandra W. Stinnett,Jina E. Swartz,Rachel L. Taylor,John Wherrett,Julie Williams,David P. Yarnall,Rachel A. Gibson,Michael C. Irizarry,Lefkos T. Middleton,Allen D. Roses +47 more
TL;DR: The genomewide association analysis again identified the APOE linkage disequilibrium region as the strongest genetic risk factor for AD.
Journal ArticleDOI
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
Sergio E. Baranzini,Joanne Wang,Rachel A. Gibson,Nicholas Galwey,Yvonne Naegelin,Frederik Barkhof,Ernst Wilhelm Radue,Raija L.P. Lindberg,Bernard Uitdehaag,Marvin Johnson,Marvin Johnson,Aspasia Angelakopoulou,Leslie Hall,Jill C. Richardson,Rab K. Prinjha,Achim Gass,Jeroen J. G. Geurts,J.J. Kragt,Madeleine H. Sombekke,Hugo Vrenken,Pamela Qualley,Robin R. Lincoln,Refujia Gomez,Stacy J. Caillier,Michaela F. George,Hourieh Mousavi,Rosa Guerrero,Darin T. Okuda,Bruce A.C. Cree,Ari J. Green,Emmanuelle Waubant,Douglas S. Goodin,Daniel Pelletier,Paul M. Matthews,Paul M. Matthews,Stephen L. Hauser,Ludwig Kappos,Chris H. Polman,Jorge R. Oksenberg +38 more
TL;DR: Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotype, and independent replication confirms a role for GPC5, a heparan sulfate proteoglycan, in disease risk.
Journal ArticleDOI
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
Sergio E. Baranzini,Nicholas Galwey,Joanne Wang,Pouya Khankhanian,Raija L.P. Lindberg,Daniel Pelletier,Wen Wu,Bernard M. J. Uitdehaag,Ludwig Kappos,Chris H. Polman,Paul M. Matthews,Stephen L. Hauser,Rachel A. Gibson,Jorge R. Oksenberg,Michael R. Barnes +14 more
TL;DR: A pathway-oriented analysis of two GWAS in MS that takes into account all SNPs with nominal evidence of association (P < 0.05) and reports here for the first time the potential involvement of neural pathways in MS susceptibility.
Journal ArticleDOI
Age at onset in two common neurodegenerative diseases is genetically controlled
Yi-Ju Li,William K. Scott,Dale J. Hedges,Fengyu Zhang,P. Craig Gaskell,Martha Nance,Ray L. Watts,Jean P. Hubble,William C. Koller,Rajesh Pahwa,Matthew B. Stern,Bradley C. Hiner,Joseph Jankovic,Fred H. Allen,Christopher G. Goetz,Frank L. Mastaglia,Jeffrey M. Stajich,Rachel A. Gibson,Lefkos T. Middleton,Ann M. Saunders,Burton L. Scott,Gary W. Small,Kristin K. Nicodemus,Allison D. Reed,Donald E. Schmechel,Kathleen A. Welsh-Bohmer,P. Michael Conneally,Allen D. Roses,John R. Gilbert,Jeffery M. Vance,Jonathan L. Haines,Margaret A. Pericak-Vance +31 more
TL;DR: The data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.