Silvia Begliuomini

TL;DR: Modifications in BDNF circulating levels during the menstrual cycle suggest a potential role for gonadal sex hormones (E(2) and progesterone) in regulating neurotrophin expression.

TL;DR: The present study is the first to demonstrate the presence of a diurnal rhythm of BDNF in humans, and the correlation found out between BDNF and cortisol circadian trend allows for speculate that these two factors may be physiologically co-regulated, in order to maintain the homeostasis of integrated cerebral activities.

TL;DR: BDNF has a diurnal variation in women that is somewhat analogous to cortisol variation; however, the amplitude of the variation in BDNF levels appears to be influenced by ovarian function.

TL;DR: The results highlight the concept that natural and synthetic progesterone receptor agonists may systematically induce different biological actions in CNS, which may have far-reaching implications for the clinical effects and related indications of each compound.

TL;DR: The identification of the brain as a de novo source of neurosteroids, suggests that the modifications in mood and cognitive performances occurring in postmenopausal women may also be related to a change in the levels of Neurosteroids.