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Silvia Grassilli
Researcher at University of Ferrara
Publications - 36
Citations - 395
Silvia Grassilli is an academic researcher from University of Ferrara. The author has contributed to research in topics: Breast cancer & Acute promyelocytic leukemia. The author has an hindex of 11, co-authored 31 publications receiving 288 citations. Previous affiliations of Silvia Grassilli include University of Rome Tor Vergata.
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Journal ArticleDOI
CD133 in Breast Cancer Cells: More than a Stem Cell Marker
Federica Brugnoli,Silvia Grassilli,Yasamin Al-Qassab,Yasamin Al-Qassab,Silvano Capitani,Valeria Bertagnolo +5 more
TL;DR: The latest findings about the implication of CD133 in breast tumors are summarized, highlighting its role in tumor cells with a triple negative phenotype in which it directly regulates the expression of proteins involved in metastasis and drug resistance.
Journal ArticleDOI
In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness.
Federica Brugnoli,Silvia Grassilli,Manuela Piazzi,Maria Palomba,Ervin Nika,Alberto Bavelloni,Silvano Capitani,Valeria Bertagnolo +7 more
TL;DR: Data showing that the forced up-regulation of PLC-β2 counteracts the invasiveness of CD133-positive MDA-MB-231 cells might contribute to identify unexplored key steps responsible for the TNBC high malignancy, to be considered for potential therapeutic strategies.
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Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation.
Federica Brugnoli,Elisabetta Lambertini,Nadine Varin-Blank,Nadine Varin-Blank,Roberta Piva,Marco Marchisio,Silvia Grassilli,Sebastiano Miscia,Silvano Capitani,Valeria Bertagnolo +9 more
TL;DR: The reported data suggest that the ATRA-induced increase of Vav1 expression and tyrosine phosphorylation may be involved in recruiting PU.1 to its consensus sequence on the CD11b promoter and, ultimately, in regulatingCD11b expression during the late stages of neutrophil differentiation of APL-derived promyelocytes.
Journal ArticleDOI
High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process.
Silvia Grassilli,Federica Brugnoli,Rossano Lattanzio,Cosmo Rossi,Letizia Perracchio,Marcella Mottolese,Marco Marchisio,Maria Palomba,Ervin Nika,Pier Giorgio Natali,Mauro Piantelli,Silvano Capitani,Valeria Bertagnolo +12 more
TL;DR: Experiments performed with breast tumor-derived cells indicated that Vav1 negatively modulates their invasiveness in vitro and their metastatic efficiency in vivo, possibly by affecting the expression of genes involved in invasion and/or metastasis of breast tumors.
Journal ArticleDOI
Vav1 modulates protein expression during ATRA-induced maturation of APL-derived promyelocytes: a proteomic-based analysis.
Valeria Bertagnolo,Silvia Grassilli,Alberto Bavelloni,Federica Brugnoli,Manuela Piazzi,Giovanni Candiano,Andrea Petretto,Mascia Benedusi,Silvano Capitani +8 more
TL;DR: An unprecedented role for Vav1 in the maturation of myeloid cells as a regulator of protein expression is indicated in the ATRA-dependent differentiation of tumoral promyelocytes.