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Silvia Stingele
Researcher at Max Planck Society
Publications - 4
Citations - 610
Silvia Stingele is an academic researcher from Max Planck Society. The author has contributed to research in topics: Ploidy & Aneuploidy. The author has an hindex of 4, co-authored 4 publications receiving 512 citations.
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Journal ArticleDOI
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
Silvia Stingele,Gabriele Stoehr,Karolina Peplowska,Jürgen Cox,Matthias Mann,Zuzana Storchova +5 more
TL;DR: The data present the first broad proteomic analysis of human cells with abnormal karyotypes and suggest a uniform cellular response to the presence of an extra chromosome.
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HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells
TL;DR: It is shown that aneuploidy impairs induction of the heat shock response suggesting that the activity of the transcription factor heat shock factor 1 (HSF1) is compromised, and deficient protein folding capacity directly shapes gene expression in aneuPLoid cells.
Journal ArticleDOI
Unique features of the transcriptional response to model aneuploidy in human cells
Milena Dürrbaum,Milena Dürrbaum,Anastasia Yurievna Kuznetsova,Verena Passerini,Silvia Stingele,Gabriele Stoehr,Gabriele Stoehr,Zuzana Storchova,Zuzana Storchova +8 more
TL;DR: The authors' analysis shows that despite the variability in chromosome content, aneuploidy triggers uniform transcriptional response in human cells, which might represent novel biomarkers to assess the malignant potential of a tumor.
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Activation of autophagy in cells with abnormal karyotype
TL;DR: Using comparative genomics, transcriptomics and proteomics, the fate of the transcripts and proteins coded on the extra chromosomes as well as the general response to aneuploidy in human cells are analyzed.