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Neysan Donnelly
Researcher at Max Planck Society
Publications - 9
Citations - 1347
Neysan Donnelly is an academic researcher from Max Planck Society. The author has contributed to research in topics: Aneuploidy & HSF1. The author has an hindex of 8, co-authored 9 publications receiving 1068 citations. Previous affiliations of Neysan Donnelly include National University of Ireland, Galway.
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Journal ArticleDOI
The eIF2α kinases: their structures and functions
TL;DR: While significant sequence similarity exists between the eIF2α kinases in their kinase domains, underlying their common role in phosphorylating eif2α, additional unique features determine the regulation of these four proteins, that is, what signals activate them.
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Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation
Erik McShane,Celine Sin,Henrick Zauber,Jonathan N. Wells,Neysan Donnelly,Xi Wang,Jingyi Hou,Wei Chen,Zuzana Storchova,Joseph A. Marsh,Angelo Valleriani,Matthias Selbach,Matthias Selbach +12 more
TL;DR: Together, the data show that non-exponentially degradation is common, conserved, and has important consequences for complex formation and regulation of protein abundance.
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The presence of extra chromosomes leads to genomic instability.
Verena Passerini,Efrat Ozeri-Galai,Mirjam S. de Pagter,Neysan Donnelly,Sarah Schmalbrock,Wigard P. Kloosterman,Batsheva Kerem,Zuzana Storchova +7 more
TL;DR: It is shown that gain of a single chromosome increases genomic instability, thereby promoting genomic instability and possibly contributing to tumorigenesis, and that restoring near-wild-type levels of chromatin-bound MCM helicase partly rescues the genomic instability phenotypes.
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HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells
TL;DR: It is shown that aneuploidy impairs induction of the heat shock response suggesting that the activity of the transcription factor heat shock factor 1 (HSF1) is compromised, and deficient protein folding capacity directly shapes gene expression in aneuPLoid cells.
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Dynamic karyotype, dynamic proteome: buffering the effects of aneuploidy.
Neysan Donnelly,Zuzana Storchova +1 more
TL;DR: The correlation between chromosome copy number changes and gene expression in aneuploid cells is examined and a novel hypothesis to explain the hitherto enigmatic abundance compensation of proteins encoded on supernumerary chromosomes is proposed.