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Silvia Tian Gan
Researcher at Brigham and Women's Hospital
Publications - 4
Citations - 488
Silvia Tian Gan is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Cancer & Photothermal therapy. The author has an hindex of 3, co-authored 4 publications receiving 316 citations. Previous affiliations of Silvia Tian Gan include University of Waterloo.
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Journal ArticleDOI
A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy.
Xiaoyuan Ji,Xiaoyuan Ji,Na Kong,Junqing Wang,Wenliang Li,Yuling Xiao,Silvia Tian Gan,Ye Zhang,Yujing Li,Xiangrong Song,Qingqing Xiong,Sanjun Shi,Zhongjun Li,Wei Tao,Han Zhang,Lin Mei,Jinjun Shi +16 more
TL;DR: This is the first report on the top‐down fabrication of ultrathin 2D B NSs by the combined thermal oxidation etching and liquid exfoliation, as well as their application as a multimodal imaging‐guided drug delivery platform.
Journal ArticleDOI
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition.
Na Kong,Na Kong,Wei Tao,Xiang Ling,Junqing Wang,Yuling Xiao,Sanjun Shi,Xiaoyuan Ji,Xiaoyuan Ji,Aram Shajii,Silvia Tian Gan,Silvia Tian Gan,Na Yoon Kim,Dan G. Duda,Tian Xie,Omid C. Farokhzad,Omid C. Farokhzad,Jinjun Shi +17 more
TL;DR: Redox-sensitive mRNA nanoparticles help kill tumors by restoring p53 expression by delivering p53-mRNA in nanoparticles and indicate that restoration of tumor suppressors by the synthetic mRNA NP delivery strategy could be combined together with other therapies for potent combinatorial cancer treatment.
Journal ArticleDOI
Comprehensive insights into intracellular fate of WS2 nanosheets for enhanced photothermal therapeutic outcomes via exocytosis inhibition
Na Kong,Li Ding,Xiaobin Zeng,Junqing Wang,Wenliang Li,Sanjun Shi,Silvia Tian Gan,Xianbing Zhu,Xianbing Zhu,Wei Tao,Xiaoyuan Ji,Xiaoyuan Ji +11 more
TL;DR: By blocking the revealed exocytosis pathway-mediated secretion of WS2 NSs in tumor cells, an effective approach is proposed to attain enhanced photothermal therapeutic outcomes with low doses of WS 2 NSs and under a low power of a near-infrared (NIR) laser.
Journal ArticleDOI
Cancer Theranostics: A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy (Adv. Mater. 36/2018)
Xiaoyuan Ji,Xiaoyuan Ji,Na Kong,Junqing Wang,Wenliang Li,Yuling Xiao,Silvia Tian Gan,Ye Zhang,Yujing Li,Xiangrong Song,Qingqing Xiong,Sanjun Shi,Zhongjun Li,Wei Tao,Han Zhang,Lin Mei,Jinjun Shi +16 more