S
Silvio Danese
Researcher at Humanitas University
Publications - 1184
Citations - 47449
Silvio Danese is an academic researcher from Humanitas University. The author has contributed to research in topics: Ulcerative colitis & Medicine. The author has an hindex of 90, co-authored 893 publications receiving 35801 citations. Previous affiliations of Silvio Danese include The Catholic University of America & Catholic University of the Sacred Heart.
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Journal ArticleDOI
Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
Silvio Danese,Miquel Sans,Carol A. de la Motte,Cristina Graziani,Gail A. West,Manijeh Phillips,Roberto Pola,Sergio Rutella,Joe Willis,Antonio Gasbarrini,Claudio Fiocchi +10 more
TL;DR: Results provide morphological, phenotypic and functional evidence of potent angiogenic activity in both CD and UC mucosa, indicating that the local microvasculature undergoes an intense process of inflammation-dependent angiogenesis.
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Inflammation and coagulation in inflammatory bowel disease: The clot thickens.
TL;DR: Overall, an overview is provided that the coagulation system represents an important, though previously underestimated, component of IBD pathogenesis, and may be a possible target for therapeutic intervention.
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Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses.
Daniele Piovani,Silvio Danese,Laurent Peyrin-Biroulet,Georgios K. Nikolopoulos,Theodore Lytras,Stefanos Bonovas +5 more
TL;DR: In an umbrella review of meta-analyses of observational studies examining environmental factors and risk of inflammatory bowel diseases, varying levels of evidence for associations of different environmental factors with risk of IBD is found.
Journal ArticleDOI
Extraintestinal manifestations in inflammatory bowel disease
Silvio Danese,Stefano Semeraro,Alfredo Papa,I. Roberto,Franco Scaldaferri,Giuseppe Fedeli,Giovanni Gasbarrini,Antonio Gasbarrini +7 more
TL;DR: How virtually almost every organ system can be involved, principally eyes, skin, joints, kidneys, liver and biliary tracts, and vasculature are the most common sites of systemic IBD and their involvement is dependent on different mechanisms is highlighted.
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Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease.
Mario Cottone,Anna Kohn,Marco Daperno,Alessandro Armuzzi,Luisa Guidi,Renata D'Incà,Fabrizio Bossa,Erika Angelucci,Livia Biancone,Paolo Gionchetti,Sandro Ardizzone,Claudio Papi,Walter Fries,Silvio Danese,Gabriele Riegler,Maria Cappello,Fabiana Castiglione,Vito Annese,Ambrogio Orlando +18 more
TL;DR: Patients older than 65 years treated with TNF inhibitors for IBD have a high rate of severe infections and mortality compared with younger patients or patients of the same age that did not receive these therapeutics.