M
Maurizio Vecchi
Researcher at Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Publications - 347
Citations - 10157
Maurizio Vecchi is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Medicine & Inflammatory bowel disease. The author has an hindex of 49, co-authored 285 publications receiving 8628 citations. Previous affiliations of Maurizio Vecchi include University of Milan & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Development of the Crohn's disease digestive damage score, the Lémann score†‡§
Benjamin Pariente,Jacques Cosnes,Silvio Danese,William J. Sandborn,Maãté Lewin,Joel G. Fletcher,Yehuda Chowers,Geert R. D'Haens,Brian G. Feagan,Toshifumi Hibi,Daniel W. Hommes,E. Jan Irvine,Michael A. Kamm,Edward V. Loftus,Edouard Louis,Pierre Michetti,Pia Munkholm,Tom Øresland,Julián Panés,Laurent Peyrin-Biroulet,Walter Reinisch,Bruce E. Sands,Juergen Schoelmerich,Stefan Schreiber,Herbert Tilg,Simon Travis,Gert Van Assche,Maurizio Vecchi,Jean Yves Mary,Jean-Frederic Colombel,Marc Lémann +30 more
TL;DR: The methods to develop an instrument that can measure cumulative bowel damage, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection are outlined.
Journal ArticleDOI
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis.
Luca Pastorelli,Rekha R. Garg,Sharon B. Hoang,Luisa Spina,Benedetta Mattioli,Melania Scarpa,Claudio Fiocchi,Maurizio Vecchi,Theresa T. Pizarro +8 more
TL;DR: The IL-33/ST2 system plays an important role in IBD and experimental colitis, is modulated by anti-TNF therapy, and may represent a specific biomarker for active UC.
Journal ArticleDOI
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Giovanni Monteleone,Markus F. Neurath,Sandro Ardizzone,Antonio Di Sabatino,Massimo Fantini,Fabiana Castiglione,Maria Lia Scribano,Alessandro Armuzzi,Flavio Caprioli,Giacomo Carlo Sturniolo,Francesca Rogai,Maurizio Vecchi,Raja Atreya,Fabrizio Bossa,Sara Onali,Maria Fichera,Gino Roberto Corazza,Livia Biancone,Vincenzo Savarino,Roberta Pica,Ambrogio Orlando,Francesco Pallone +21 more
TL;DR: It was found that study participants with Crohn's disease who received mongersen had significantly higher rates of remission and clinical response than those who received placebo.
Journal ArticleDOI
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics.
Luca Pastorelli,Luca Pastorelli,Carlo De Salvo,Joseph R. Mercado,Maurizio Vecchi,Theresa T. Pizarro +5 more
TL;DR: Several recently proposed therapeutic approaches to treat human IBD are targeted at enhancing different elements of gut barrier function, further supporting a primary role of the epithelium in the pathogenesis of chronic intestinal inflammation and emphasizing the importance of maintaining a healthy and effective intestinal barrier.
Journal ArticleDOI
Inflammation and coagulation in inflammatory bowel disease: The clot thickens.
TL;DR: Overall, an overview is provided that the coagulation system represents an important, though previously underestimated, component of IBD pathogenesis, and may be a possible target for therapeutic intervention.