Silvio De Flora

TL;DR: The potential cardiovascular toxicities for a range of cancer chemotherapeutic and chemopreventive agents are summarized and the importance of evaluating cardiovascular risk when patients enter into trials is emphasized and the need to develop guidelines that include collateral effects on the cardiovascular system is emphasized.

TL;DR: Changes in microRNA expression are an early event following exposure to cigarette smoke, and there was a strong parallelism in dysregulation of rodent microRNAs and their human homologues, which are often transcribed from genes localized in fragile sites deleted in lung cancer.

TL;DR: This article reviews approximately 700 results reported in the literature with 32 chromium compounds assayed in 130 short-term tests, using different targets and/or genetic end-points, to provide useful information for predicting and interpreting the peculiar patterns of Cr(VI) carcinogenicity.

TL;DR: On the whole, there is overwhelming evidence that NAC has the ability to modulate a variety of DNA damage- and cancer-related end-points, as evaluated in in vitro test systems, experimental animals and clinical trials.

TL;DR: It is hypothesized that other chemopreventive agents, including natural or synthetic retinoids, steroid hormone antagonists, peroxisome proliferator‐activated receptor γ li‐gands, vitamin D, and protease inhibitors, might have antiangiogenesis as an important mechanism of action, a novel concept the authors will term ‘angioprevention’.