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Simon Cuhlmann
Researcher at Imperial College London
Publications - 12
Citations - 911
Simon Cuhlmann is an academic researcher from Imperial College London. The author has contributed to research in topics: Endothelium & Inflammation. The author has an hindex of 10, co-authored 12 publications receiving 830 citations. Previous affiliations of Simon Cuhlmann include British Heart Foundation & National Institutes of Health.
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Journal ArticleDOI
Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Mustafa Zakkar,Kim Van der Heiden,Le Anh Luong,Hera Chaudhury,Simon Cuhlmann,Shahir S. Hamdulay,Rob Krams,Indika Edirisinghe,Irfan Rahman,Harald Carlsen,Dorian O. Haskard,Justin C. Mason,Paul C. Evans +12 more
TL;DR: Nrf2 prevents ECs at the atheroprotected site from exhibiting a proinflammatory state via the suppression of p38–VCAM-1 signaling, and may provide a novel therapeutic strategy to prevent or reduce atherosclerosis.
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Role of nuclear factor κB in cardiovascular health and disease
TL;DR: The present review will focus on recent studies on the function of NF-kappaB in the cardiovascular system, which has divergent functions and can protect cardiovascular tissues from injury or contribute to pathogenesis depending on the cellular and physiological context.
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Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis
Mustafa Zakkar,Hera Chaudhury,Gunhild Sandvik,Karine Enesa,Le Anh Luong,Simon Cuhlmann,Justin C. Mason,Rob Krams,Andrew R. Clark,Dorian O. Haskard,Paul C. Evans +10 more
TL;DR: The findings reveal a novel molecular mechanism contributing to the spatial distribution of vascular inflammation and atherosclerosis, and MKP-1 induction is required for the antiinflammatory effects of shear stress.
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Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1 A Novel Mode of NF-κB Regulation That Promotes Arterial Inflammation
Simon Cuhlmann,Kim Van der Heiden,David Saliba,Jordi L. Tremoleda,Magdy T. Khalil,Mustafa Zakkar,Hera Chaudhury,Le Anh Luong,Justin C. Mason,Irina A. Udalova,Willy Gsell,Hazel A. Jones,Dorian O. Haskard,Rob Krams,Paul C. Evans +14 more
TL;DR: In this paper, the authors studied the signaling mechanisms that regulate RelA NF-κB subunit expression in endothelial cells (ECs) and their role in arterial inflammation, and they demonstrated that disturbed blood flow promotes arterial inflammatory response by inducing RelA expression via JNK-ATF2 signaling.
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Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
Anna Pfenniger,Cindy W Wong,Esther Sutter,Simon Cuhlmann,Sylvie Dunoyer-Geindre,François Mach,Anton J.G. Horrevoets,Paul C. Evans,Rob Krams,Brenda R. Kwak +9 more
TL;DR: The effect of shear stress on Cx37 expression may contribute to the synchronization of ECs and participate in the protective effect of HLSS.