P
Paul C. Evans
Researcher at University of Sheffield
Publications - 187
Citations - 10363
Paul C. Evans is an academic researcher from University of Sheffield. The author has contributed to research in topics: Inflammation & Endothelium. The author has an hindex of 46, co-authored 176 publications receiving 8292 citations. Previous affiliations of Paul C. Evans include Royal Hallamshire Hospital & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Piezo1 integration of vascular architecture with physiological force
Jing Li,Bing Hou,Sarka Tumova,Katsuhiko Muraki,Alexander F. Bruns,Melanie J. Ludlow,Alicia Sedo,Adam J. Hyman,Lynn McKeown,Richard S. Young,Richard S. Young,Nadira Yuldasheva,Yasser Majeed,Lesley A. Wilson,Baptiste Rode,Marc A. Bailey,Hyejeong R. Kim,Zhaojun Fu,Deborah Angela Louise Carter,Jan Bilton,Helen Imrie,Paul Ajuh,T. Neil Dear,Richard M Cubbon,Mark T. Kearney,K. Raj Prasad,Paul C. Evans,Justin F. X. Ainscough,David J. Beech +28 more
TL;DR: Piezo1 channels are shown as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology and the data suggest that Piezo 1 channels function as pivotal integrators in vascular biology.
Journal ArticleDOI
Microchimerism and HLA-compatible relationships of pregnancy in scleroderma
J. Lee Nelson,J. Lee Nelson,Daniel E. Furst,Sean Maloney,Ted Gooley,Paul C. Evans,Anajane G. Smith,Michael A. Bean,Carole Ober,Diana W. Bianchi +9 more
TL;DR: The finding that HLA class II compatibility of a child was more common for scleroderma patients than for controls, supports the possibility that microchimerism may be involved in the pathogenesis of sclerodma.
Journal ArticleDOI
Microchimerism of maternal origin persists into adult life
Sean Maloney,Anajane G. Smith,Daniel E. Furst,David Myerson,Kate Rupert,Paul C. Evans,J. Lee Nelson +6 more
TL;DR: Sensitive human leukocyte antigen-specific PCR assays and targeted nonshared maternal HLA genes to test for persistent maternal microchimerism indicate that HLA-disparate maternal cells can persist in immunocompetent offspring well into adult life.
Journal ArticleDOI
Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma
TL;DR: Fetal microchimerism in the face of HLA disparity implies that specific maternal immunoregulatory pathways exist that permit persistence but prevent effector function of these cells in normal women.
Journal ArticleDOI
Biomechanical factors in atherosclerosis: mechanisms and clinical implications.
Brenda R. Kwak,Magnus Bäck,Marie-Luce Bochaton-Piallat,Giuseppina Caligiuri,Mat J.A.P. Daemen,Peter F. Davies,Imo E. Hoefer,Paul Holvoet,Hanjoong Jo,Rob Krams,Stephanie Lehoux,Claudia Monaco,Sabine Steffens,Renu Virmani,Christian Weber,Jolanda J. Wentzel,Paul C. Evans +16 more
TL;DR: The current 'state of the art' on the interface between mechanical forces and atherosclerotic plaque biology is summarized and potential clinical applications and key questions for future research are identified.