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Simon M. Plummer
Researcher at University of Leicester
Publications - 18
Citations - 3200
Simon M. Plummer is an academic researcher from University of Leicester. The author has contributed to research in topics: Curcumin & DNA. The author has an hindex of 14, co-authored 18 publications receiving 3044 citations.
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Journal ArticleDOI
Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance
Ricky A. Sharma,Stephanie A. Euden,Sharon L. Platton,Darren N. Cooke,Aisha Shafayat,Heather R. Hewitt,Timothy H. Marczylo,Bruno Morgan,David Hemingway,Simon M. Plummer,Munir Pirmohamed,Andreas J. Gescher,William P. Steward +12 more
TL;DR: A daily oral dose of 3.6 g of curcumin is advocated for Phase II evaluation in the prevention or treatment of cancers outside the gastrointestinal tract in patients with advanced colorectal cancer refractory to standard chemotherapies.
Journal ArticleDOI
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.
Simon M. Plummer,Karen A. Holloway,Margaret M. Manson,Rebecca Jl Munks,Allard Kaptein,Stuart N. Farrow,Lynne M. Howells +6 more
TL;DR: Curcumin inhibits COX2 induction by the colon tumour promoters, tumour necrosis factor α or fecapentaene-12, making curcumin an important candidate for consideration in colon cancer prevention.
Journal Article
Characterization of Metabolites of the Chemopreventive Agent Curcumin in Human and Rat Hepatocytes and in the Rat in Vivo, and Evaluation of Their Ability to Inhibit Phorbol Ester-induced Prostaglandin E2 Production
Christopher R. Ireson,Samantha Orr,Donald J. L. Jones,Richard D. Verschoyle,C. K. Lim,Jin-Li Luo,Lynne M. Howells,Simon M. Plummer,Rebekah Jukes,Marion L. Williams,William P. Steward,Andreas J. Gescher +11 more
TL;DR: The results support the clinical evaluation of curcumin as a colorectal cancer chemopreventive agent and test the hypothesis that curCumin metabolites resemble their progenitor in that they can inhibit COX-2 expression.
Journal ArticleDOI
Blocking and suppressing mechanisms of chemoprevention by dietary constituents.
Margaret M. Manson,Andreas J. Gescher,E A Hudson,Simon M. Plummer,M. S. Squires,Sally A. Prigent +5 more
TL;DR: The likelihood of success in chemoprevention trials and in provision of dietary advice to the general population to optimise the chances of preventing disease is increased.
Journal ArticleDOI
Suppression of tumour development by substances derived from the diet—mechanisms and clinical implications
TL;DR: In this article, the authors discuss mechanisms by which the soya constituent genistein, the curry ingredient curcumin and the vitamin A analogue 13-cis retinoic acid exert tumour suppression.