B
Bruno Morgan
Researcher at University of Leicester
Publications - 52
Citations - 4371
Bruno Morgan is an academic researcher from University of Leicester. The author has contributed to research in topics: Angiography & Cancer. The author has an hindex of 25, co-authored 51 publications receiving 3801 citations. Previous affiliations of Bruno Morgan include Jagiellonian University Medical College & University of Freiburg.
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Journal ArticleDOI
Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance
Ricky A. Sharma,Stephanie A. Euden,Sharon L. Platton,Darren N. Cooke,Aisha Shafayat,Heather R. Hewitt,Timothy H. Marczylo,Bruno Morgan,David Hemingway,Simon M. Plummer,Munir Pirmohamed,Andreas J. Gescher,William P. Steward +12 more
TL;DR: A daily oral dose of 3.6 g of curcumin is advocated for Phase II evaluation in the prevention or treatment of cancers outside the gastrointestinal tract in patients with advanced colorectal cancer refractory to standard chemotherapies.
Journal ArticleDOI
Imaging biomarker roadmap for cancer studies.
James P B O'Connor,Eric O. Aboagye,Judith E. Adams,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Sally F. Barrington,Ambros J. Beer,Ronald Boellaard,Sarah E. Bohndiek,J. Michael Brady,Gina Brown,David L. Buckley,Thomas L. Chenevert,Laurence P. Clarke,Sandra Collette,Gary Cook,Nandita M. deSouza,John Dickson,Caroline Dive,Jeffrey L. Evelhoch,Corinne Faivre-Finn,Ferdia A. Gallagher,Fiona J. Gilbert,Robert J. Gillies,Vicky Goh,John R. Griffiths,Ashley M. Groves,Steve Halligan,Adrian L. Harris,David J. Hawkes,Otto S. Hoekstra,Erich P. Huang,Brian Hutton,Edward F. Jackson,Gordon C Jayson,Andrew J. I. Jones,Dow-Mu Koh,Denis Lacombe,Philippe Lambin,Nathalie Lassau,Martin O. Leach,Ting-Yim Lee,Edward Leen,Jason S. Lewis,Yan Liu,Mark F. Lythgoe,Prakash Manoharan,Ross J. Maxwell,Kenneth A. Miles,Bruno Morgan,Steve Morris,Tony Ng,Anwar R. Padhani,Geoff J M Parker,Mike Partridge,Arvind P. Pathak,Arvind P. Pathak,Andrew C. Peet,Shonit Punwani,Andrew R. Reynolds,Simon P. Robinson,Lalitha K. Shankar,Ricky A. Sharma,Dmitry Soloviev,Sigrid Stroobants,Daniel C. Sullivan,Stuart A. Taylor,Paul S. Tofts,Gillian M. Tozer,Marcel van Herk,Simon Walker-Samuel,James Wason,Kaye J. Williams,Paul Workman,Thomas E. Yankeelov,Kevin M. Brindle,Lisa M. McShane,Alan Jackson,John C. Waterton +78 more
TL;DR: Experts assembled to review, debate and summarize the challenges of IB validation and qualification produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical validation, biological/clinical validation and assessment of cost-effectiveness.
Journal ArticleDOI
Radioembolization of Liver Metastases From Colorectal Cancer Using Yttrium-90 Microspheres With Concomitant Systemic Oxaliplatin, Fluorouracil, and Leucovorin Chemotherapy
Ricky A. Sharma,Guy van Hazel,Bruno Morgan,David P. Berry,Keith Blanshard,David H. Price,Geoffrey C. Bower,Jennifer Shannon,Peter Gibbs,William P. Steward +9 more
TL;DR: A phase I study of SIR-Spheres therapy with modified FOLFOX4 systemic chemotherapy in patients with inoperable liver metastases from CRC who had not previously received chemotherapy for metastatic disease concluded that this chemoradiation regime merits evaluation in phase II-III trials.
Journal ArticleDOI
Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PTK787/ZK 222584 Administered Twice Daily in Patients With Advanced Cancer
Anne L. Thomas,Bruno Morgan,Mark A. Horsfield,Anthony Higginson,Andrea C. Kay,Lucy Lee,Eric Masson,Marie Puccio-Pick,Dirk Laurent,William P. Steward +9 more
TL;DR: DCE-MRI and pharmacokinetic data indicate that the maximum-tolerated oral dose of PTK/ZK >/= 1,000 mg total daily dose is the biologically active dose.
Journal ArticleDOI
Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study
Mariam Jamal-Hanjani,Alan Hackshaw,Yenting Ngai,Jacqueline A Shaw,Caroline Dive,Sergio A. Quezada,Gary Middleton,Elza C de Bruin,John Le Quesne,Seema Shafi,Mary Falzon,Stuart Horswell,Fiona H Blackhall,Iftekhar Khan,Sam M. Janes,Marianne Nicolson,David Lawrence,Martin Forster,Dean A. Fennell,Siow Ming Lee,Jason F. Lester,Keith M. Kerr,Salli Muller,Natasha Iles,Sean W. Smith,Nirupa Murugaesu,Richard Mitter,Max Salm,Aengus Stuart,Nik Matthews,Haydn Adams,Tanya Ahmad,Richard Attanoos,Jonathan Bennett,Nicolai Juul Birkbak,Richard Booton,Ged Brady,Keith Buchan,Arrigo Capitano,Mahendran Chetty,Mark Cobbold,Philip A.J. Crosbie,Helen E. Davies,A R Denison,Madhav Djearman,Jacki Goldman,Tom Haswell,Leena Dennis Joseph,Malgorzata Kornaszewska,Matthew G Krebs,Gerald Langman,Mairead MacKenzie,Joy Millar,Bruno Morgan,Babu Naidu,Daisuke Nonaka,Karl S. Peggs,Catrin Pritchard,Hardy Remmen,Andrew Rowan,Rajesh Shah,Elaine Smith,Yvonne Summers,Magali Taylor,Selvaraju Veeriah,David A. Waller,Ben Wilcox,Maggie Wilcox,Ian Woolhouse,Nicholas McGranahan,Charles Swanton +70 more
TL;DR: TRACERx, a prospective study of patients with primary non-small cell lung cancer, aims to map the genomic landscape of lung cancer by tracking clonal heterogeneity and tumour evolution from diagnosis to relapse.