Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Data Mining - Concepts and Techniques.

The organization of behavior: A neuropsychological theory

DLS and zeta potential - What they are and what they are not?

We present a new algorithm for manifold learning and nonlinear dimensionality reduction. Based on a set of unorganized da-ta points sampled with noise from a parameterized manifold, the local geometry of the manifold is learned by constructing an approxi-mation for the tangent space at each point, and those tangent spaces are then aligned to give the global coordinates of the data pointswith respect to the underlying manifold. We also present an error analysis of our algorithm showing that reconstruction errors can bequite small in some cases. We illustrate our algorithm using curves and surfaces both in 2D/3D Euclidean spaces and higher dimension-al Euclidean spaces. We also address several theoretical and algorithmic issues for further research and improvements.

Principal Manifolds and Nonlinear Dimensionality Reduction via Tangent Space Alignment

In recent years, the range of sensing technologies has expanded rapidly, whereas sensor devices have become cheaper. This has led to a rapid expansion in condition monitoring of systems, structures, vehicles, and machinery using sensors. Key factors are the recent advances in networking technologies such as wireless communication and mobile ad hoc networking coupled with the technology to integrate devices. Wireless sensor networks (WSNs) can be used for monitoring the railway infrastructure such as bridges, rail tracks, track beds, and track equipment along with vehicle health monitoring such as chassis, bogies, wheels, and wagons. Condition monitoring reduces human inspection requirements through automated monitoring, reduces maintenance through detecting faults before they escalate, and improves safety and reliability. This is vital for the development, upgrading, and expansion of railway networks. This paper surveys these wireless sensors network technology for monitoring in the railway industry for analyzing systems, structures, vehicles, and machinery. This paper focuses on practical engineering solutions, principally, which sensor devices are used and what they are used for; and the identification of sensor configurations and network topologies. It identifies their respective motivations and distinguishes their advantages and disadvantages in a comparative review.

/pdf/wireless-sensor-networks-for-condition-monitoring-in-the-2he64b3jue.pdf

Wireless Sensor Networks for Condition Monitoring in the Railway Industry: A Survey

https://eprints.whiterose.ac.uk/46265/1/Lampert10Survey.pdf

A survey of spectrogram track detection algorithms

The need for reproducible and comparable results is of increasing importance in non-targeted metabolomic studies, especially when differences between experimental groups are small. Liquid chromatography–mass spectrometry spectra are often acquired batch-wise so that necessary calibrations and cleaning of the instrument can take place. However this may introduce further sources of variation, such as differences in the conditions under which the acquisition of individual batches is performed. Quality control (QC) samples are frequently employed as a means of both judging and correcting this variation. Here we show that the use of QC samples can lead to problems. The non-linearity of the response can result in substantial differences between the recorded intensities of the QCs and experimental samples, making the required adjustment difficult to predict. Furthermore, changes in the response profile between one QC interspersion and the next cannot be accounted for and QC based correction can actually exacerbate the problems by introducing artificial differences. “Background correction” methods utilise all experimental samples to estimate the variation over time rather than relying on the QC samples alone. We compare non-QC correction methods with standard QC correction and demonstrate their success in reducing differences between replicate samples and their potential to highlight differences between experimental groups previously hidden by instrumental variation.

/pdf/a-batch-correction-method-for-liquid-chromatography-mass-3fvvgt2q8n.pdf

A batch correction method for liquid chromatography–mass spectrometry data that does not depend on quality control samples

Motivation: The identification of suitable conditions for crystallization is a rate-limiting step in protein structure determination. The pH of an experiment is an important parameter and has the potential to be used in data-mining studies to help reduce the number of crystallization trials required. However, the pH is usually recorded as that of the buffer solution, which can be highly inaccurate.

Results: Here, we show that a better estimate of the true pH can be predicted by considering not only the buffer pH but also any other chemicals in the crystallization solution. We use these more accurate pH values to investigate the disputed relationship between the pI of a protein and the pH at which it crystallizes.

Availability and implementation: Data used to generate models are available as Supplementary Material.

Contact: ku.ca.kroy@nosliw.eiluj

Supplementary information: Supplementary data are available at Bioinformatics online.

https://www.science-open.com/document_file/44ad1081-5015-4b6d-96a8-ea405e92d653/PubMedCentral/44ad1081-5015-4b6d-96a8-ea405e92d653.pdf

Simon O'Keefe

Papers

Wireless Sensor Networks for Condition Monitoring in the Railway Industry: A Survey

A survey of spectrogram track detection algorithms

A batch correction method for liquid chromatography–mass spectrometry data that does not depend on quality control samples

Using isoelectric point to determine the pH for initial protein crystallization trials

Hadoop neural network for parallel and distributed feature selection