Simona Aufiero

TL;DR: Owing to their high stability and abundance in bodily fluids, circRNAs have potential as useful biomarkers for various diseases, including cardiovascular disease.

TL;DR: It is shown that RBM20 is crucial for the formation of a subset of circRNAs that originate from the I-band of the titin gene, a novel class of noncoding RNA molecules in the heart that is dynamically regulated in dilated cardiomyopathy but not in hypertrophic heart disease.

TL;DR: The experimental data suggest that RBM20 mutation carriers may benefit from treatment with an ICa,L blocker to reduce their arrhythmia burden and suggest that patients that carry a pathogenic R BM20 mutation have more ventricular arrhythmias despite a similar left ventricular function, in comparison with patients with a TTN mutation.

TL;DR: It is shown that cardiac circ RNAs are mostly derived from constitutive exons, suggesting that these circRNAs are generated at the expense of their linear counterpart and that circRNA production impacts the accumulation of the linear mRNA.

TL;DR: Overall, the circRNA analysis workflow implemented by circRNAprofiler is highly automated and customizable, and the results of the analyses can be used as starting point for further investigation in the role of specific circRNAs in any physiological or pathological condition.