J
Johannes Backs
Researcher at Heidelberg University
Publications - 146
Citations - 9119
Johannes Backs is an academic researcher from Heidelberg University. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Heart failure. The author has an hindex of 45, co-authored 126 publications receiving 7493 citations. Previous affiliations of Johannes Backs include University of Texas at Dallas & University Hospital Heidelberg.
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Journal ArticleDOI
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
TL;DR: It is shown that calcium/calmodulin-dependent kinase II (CaMKII) signals specifically to HDAC4 by binding to a unique docking site that is absent in other class IIa HDACs, revealing a central role forHDAC4 in CaMKII signaling pathways and have implications for the control of gene expression by calcium signaling in a variety of cell types.
Journal ArticleDOI
The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
Johannes Backs,Thea Backs,Thea Backs,Stefan Neef,Michael M. Kreusser,Lorenz H. Lehmann,David M. Patrick,Chad E. Grueter,Xiaoxia Qi,James A. Richardson,Joseph A. Hill,Hugo A. Katus,Rhonda Bassel-Duby,Lars S. Maier,Eric N. Olson +14 more
TL;DR: It is concluded that CaMKIIδ functions as an important transducer of stress stimuli involved in pathological cardiac remodeling in vivo, which is mediated, at least in part, by the phosphorylation of HDAC4.
Journal ArticleDOI
Control of Cardiac Growth by Histone Acetylation/Deacetylation
Johannes Backs,Eric N. Olson +1 more
TL;DR: Manipulation of histone modifying enzymes and the signaling pathways that impinge on them in the settings of pathological cardiac growth, remodeling, and heart failure represents an auspicious therapeutic approach.
Journal ArticleDOI
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
Jenelle M. Timmins,Lale Ozcan,Tracie A. Seimon,Gang Li,Cristina Malagelada,Johannes Backs,Thea Backs,Rhonda Bassel-Duby,Eric N. Olson,Mark E. Anderson,Ira Tabas +10 more
TL;DR: It is shown that cytosolic calcium resulting from ER stress induces expression of the Fas death receptor through a pathway involving calcium/calmodulin-dependent protein kinase IIgamma (CaMKIIgamma) and JNK, and these findings raise the possibility that CaMKII inhibitors could be useful in preventing apoptosis in pathological settings involving ER stress-induced apoptosis.
Journal ArticleDOI
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.
Matthew J. Potthoff,Hai Wu,Michael Arnold,John M. Shelton,Johannes Backs,John R. McAnally,James A. Richardson,Rhonda Bassel-Duby,Eric N. Olson +8 more
TL;DR: The selective degradation of class II HDACs in slow skeletal muscle provides a mechanism for enhancing physical performance and resistance to fatigue by augmenting the transcriptional activity of MEF2.