S
Simone B. Sartori
Researcher at University of Innsbruck
Publications - 55
Citations - 2213
Simone B. Sartori is an academic researcher from University of Innsbruck. The author has contributed to research in topics: Anxiety & Anxiolytic. The author has an hindex of 25, co-authored 50 publications receiving 1923 citations. Previous affiliations of Simone B. Sartori include University of Regensburg.
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Journal ArticleDOI
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Martina J. Sinnegger-Brauns,Irene G. Huber,Alexandra Koschak,Claudia Wild,Gerald J. Obermair,Ursula Einzinger,Jean-Charles Hoda,Simone B. Sartori,Joerg Striessnig +8 more
TL;DR: Small differences in their binding pockets may allow development of isoform-selective modulators for LTCCs and that, because of their very low expression, Cav.1.1 and Cav1.4 are unlikely to serve as drug targets to treat CNS diseases.
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Magnesium-deficient diet alters depression- and anxiety-related behavior in mice—influence of desipramine and Hypericum perforatum extract
TL;DR: It is reported that Mg-depletion leads to enhanced depression- and anxiety-related behavior in mice, which was further validated by the reversibility of the behavioral changes by known antidepressant and anxiolytic substances.
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The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression.
Ramon O. Tasan,Ngoc Khoi Nguyen,Stefan Weger,Simone B. Sartori,Nicolas Singewald,Regine Heilbronn,Herbert Herzog,Giinther Sperk +7 more
TL;DR: Evidence is found of the highly site-specific nature of the Y2-mediated function of NPY in the modulation of anxiety- and depression-related behavior.
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Functional Properties of a Newly Identified C-terminal Splice Variant of Cav1.3 L-type Ca2+ Channels
Gabriella Bock,Mathias Gebhart,Anja Scharinger,Wanchana Jangsangthong,Perrine Busquet,Chiara Poggiani,Simone B. Sartori,Matteo E. Mangoni,Martina J. Sinnegger-Brauns,Stefan Herzig,Joerg Striessnig,Alexandra Koschak +11 more
TL;DR: The discovery of a novel short splice variant that is expressed at high levels in the brain but not in the heart is described and may help to fine tune Ca2+ channel signaling and, in the case of short variants lacking a functional C-terminal modulation, prevent excessiveCa2+ accumulation during burst firing in neurons.
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Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
TL;DR: The present findings demonstrate the robustness and validity of the Mg2+ deficiency model as a mouse model of enhanced anxiety, showing sensitivity to treatment with anxiolytics and antidepressants and it is suggested that dysregulations in the HPA axis may contribute to the hyper-emotionality in response to dietary induced hypomagnesaemia.