Nicolas Singewald

TL;DR: Emerging concepts of the neuronal circuitry of fear extinction are reviewed, and novel findings suggesting that the fragile phenomenon of extinction can be converted into a permanent erasure of fear memories are highlighted.

TL;DR: The results suggest that the anxiogenic drugs selected activate a restricted set of forebrain areas that are consistent with the theory of an integrated forebrain and hindbrain neuronal system that is important for anxiety states evoked by both drug and environmental manipulations.

TL;DR: The current body of research reveals important new insights into the neurobiology and neurochemistry of fear extinction and holds significant promise for pharmacologically-augmented psychotherapy as an improved approach to treat trauma and anxiety-related disorders in a more efficient and persistent way promoting enhanced symptom remission and recovery.

TL;DR: It was hypothesised that blockade of NK1 receptors may attenuate stress responses and exert anxiolytic-like effects and preclinical and clinical studies have found evidence in favour of such an assumption.

TL;DR: A deficit in fear extinction in 129S1 is demonstrated associated with a failure to properly engage corticolimbic extinction circuitry, and this common inbred strain provides a novel model for studying impairedFear extinction in anxiety disorders.