S
Simone Bächler
Researcher at University of Vienna
Publications - 4
Citations - 316
Simone Bächler is an academic researcher from University of Vienna. The author has contributed to research in topics: Topoisomerase & DNA damage. The author has an hindex of 4, co-authored 4 publications receiving 290 citations.
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Journal ArticleDOI
Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
Andrea Kurzwernhart,Wolfgang Kandioller,Caroline Bartel,Simone Bächler,Robert Trondl,Gerhard Mühlgassner,Michael A. Jakupec,Vladimir B. Arion,Doris Marko,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +11 more
TL;DR: Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised and are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
Journal ArticleDOI
Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands
Andrea Kurzwernhart,Wolfgang Kandioller,Simone Bächler,Caroline Bartel,Sanela Martic,Magdalena Buczkowska,Gerhard Mühlgassner,Michael A. Jakupec,Heinz-Bernhard Kraatz,Patrick J. Bednarski,Vladimir B. Arion,Doris Marko,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +14 more
TL;DR: Compared to the flavonol ligands, the RuII(η6-p-cymene) complexes are more potent antiproliferative agents, which can be explained by potential multitargeted properties.
Journal ArticleDOI
Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells.
Melanie Esselen,Ute Boettler,Nicole Teller,Simone Bächler,Melanie Hutter,Corinna E. Rüfer,S. Skrbek,Doris Marko +7 more
TL;DR: The suppression of hydrogen peroxide accumulation, achieved by the addition of catalase, demonstrated that cyanidin does not exhibit DNA-damaging properties in HT29 cells (up to 100 μM), and the observed effects on topoisomerase interference and DNA protection against CPT or DOX were clearly limited to the parent compound and were not observed for the potential cyanidIn degradation products PGA and PCA.
Journal ArticleDOI
Role of topoisomerase inhibition and DNA repair mechanisms in the genotoxicity of alternariol and altertoxin-II
Christine Tiessen,Helge Gehrke,Christopher Kropat,Christoph Schwarz,Simone Bächler,Markus Fehr,Gudrun Pahlke,Doris Marko +7 more
TL;DR: The role of DNA repair pathways for the extent of DNA damage by AOH is investigated and the question whether interference with topoisomerase II might play a role in the genotoxicity of ALTX-II is addressed.