G
Gerhard Mühlgassner
Researcher at University of Vienna
Publications - 10
Citations - 686
Gerhard Mühlgassner is an academic researcher from University of Vienna. The author has contributed to research in topics: Ruthenium & Osmium. The author has an hindex of 9, co-authored 10 publications receiving 624 citations. Previous affiliations of Gerhard Mühlgassner include Medical University of Vienna.
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Journal ArticleDOI
Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
Andrea Kurzwernhart,Wolfgang Kandioller,Caroline Bartel,Simone Bächler,Robert Trondl,Gerhard Mühlgassner,Michael A. Jakupec,Vladimir B. Arion,Doris Marko,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +11 more
TL;DR: Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised and are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
Journal ArticleDOI
Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands
Andrea Kurzwernhart,Wolfgang Kandioller,Simone Bächler,Caroline Bartel,Sanela Martic,Magdalena Buczkowska,Gerhard Mühlgassner,Michael A. Jakupec,Heinz-Bernhard Kraatz,Patrick J. Bednarski,Vladimir B. Arion,Doris Marko,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +14 more
TL;DR: Compared to the flavonol ligands, the RuII(η6-p-cymene) complexes are more potent antiproliferative agents, which can be explained by potential multitargeted properties.
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A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines
Werner Ginzinger,Gerhard Mühlgassner,Vladimir B. Arion,Michael A. Jakupec,Alexander Roller,Markus Galanski,Michael R. Reithofer,Walter Berger,Bernhard K. Keppler +8 more
TL;DR: complexation with osmium of quinoxalinone derivatives with benzimidazole or benzothiazole results in a more consistent increase in cytotoxicity than complexation with ruthenium, whereas cell cycle effects are only moderate.
Journal ArticleDOI
Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy.
Wolfgang F. Schmid,Roland O. John,Gerhard Mühlgassner,Petra Heffeter,Michael A. Jakupec,Markus Galanski,Walter Berger,Vladimir B. Arion,Bernhard K. Keppler +8 more
TL;DR: Antiproliferative activity in the low micromolar range was observed in vitro in three human cancer cell lines by means of MTT assays, and H-Thymidine incorporation assays revealed the compounds to lower the rate of DNA synthesis, and flow cytometric analyses showed cell cycle arrest mainly in G 0/ G 1 phase.
Journal ArticleDOI
Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
Gerhard Mühlgassner,Caroline Bartel,Wolfgang F. Schmid,Michael A. Jakupec,Vladimir B. Arion,Bernhard K. Keppler +5 more
TL;DR: The BrdU assay showed that 1 is the most and 4 the least effective of these compounds regarding inhibition of DNA synthesis, although concentration-dependent inhibition of Cdk2/cyclin E activity was observed in cell-free experiments.