S
Siv H. Jacobsen
Researcher at University of Copenhagen
Publications - 15
Citations - 2038
Siv H. Jacobsen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Type 2 diabetes & Postprandial. The author has an hindex of 14, co-authored 15 publications receiving 1829 citations. Previous affiliations of Siv H. Jacobsen include Hvidovre Hospital & Novo Nordisk Foundation.
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Journal ArticleDOI
Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects
Siv H. Jacobsen,Sarah C Olesen,Carsten Dirksen,Nils B. Jørgensen,Kirstine N. Bojsen-Møller,Urd Kielgast,Dorte Worm,Thomas Almdal,Lars Naver,Lisbeth E. Hvolris,Jens F. Rehfeld,Birgitte Schjellerup Wulff,Trine R. Clausen,D.L. Hansen,J. J. Holst,Sten Madsbad +15 more
TL;DR: Within 2 weeks after RYGB, an increase in insulin secretion and insulin sensitivity was found and Responses of appetite-regulating intestinal hormones changed dramatically, all in the direction of reducing hunger.
Journal ArticleDOI
Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance
Nils B. Jørgensen,Nils B. Jørgensen,Siv H. Jacobsen,Siv H. Jacobsen,Carsten Dirksen,Carsten Dirksen,Kirstine N. Bojsen-Møller,Kirstine N. Bojsen-Møller,Lars Naver,L. Hvolris,Trine R. Clausen,Birgitte Schjellerup Wulff,Dorte Worm,D. Lindqvist Hansen,Sten Madsbad,J. J. Holst +15 more
TL;DR: Improvement in glycemic control in T2D after RYGB occurs within days after surgery and is associated with increased insulin sensitivity and improved β-cell function, the latter of which may be explained by dramatic increases in GLP-1 secretion.
Journal ArticleDOI
Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes
Nils B. Jørgensen,Nils B. Jørgensen,Carsten Dirksen,Carsten Dirksen,Kirstine N. Bojsen-Møller,Kirstine N. Bojsen-Møller,Siv H. Jacobsen,Siv H. Jacobsen,Dorte Worm,D.L. Hansen,Viggo B. Kristiansen,Lars Naver,Sten Madsbad,Jens J. Holst +13 more
TL;DR: The exaggerated effect of GLP-1 after RYGB is of major importance for the improvement in β-cell function, control of glucagon release, and glucose tolerance in patients with type 2 diabetes.
Journal ArticleDOI
Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass.
Carsten Dirksen,Nils B. Jørgensen,Kirstine N. Bojsen-Møller,Urd Kielgast,Siv H. Jacobsen,Trine R. Clausen,Dorte Worm,Bolette Hartmann,Jens F. Rehfeld,Morten Damgaard,Jan L. Madsen,Sten Madsbad,Jens J. Holst,D.L. Hansen +13 more
TL;DR: Favorable meal-induced changes in hunger and gut hormone release in patients with good compared with poor weight loss response support the role of gut hormones in the weight loss after RYGB.
Journal ArticleDOI
Early Enhancements of Hepatic and Later of Peripheral Insulin Sensitivity Combined With Increased Postprandial Insulin Secretion Contribute to Improved Glycemic Control After Roux-en-Y Gastric Bypass
Kirstine N. Bojsen-Møller,Kirstine N. Bojsen-Møller,Carsten Dirksen,Carsten Dirksen,Nils B. Jørgensen,Nils B. Jørgensen,Siv H. Jacobsen,Siv H. Jacobsen,Annette K. Serup,Peter H. Albers,Peter H. Albers,D.L. Hansen,Dorte Worm,Lars Naver,Viggo B. Kristiansen,Jørgen F. P. Wojtaszewski,Bente Kiens,Jens J. Holst,Erik A. Richter,Sten Madsbad +19 more
TL;DR: Within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity, and increased insulin clearance, highlighting the liver as an important organ responsible for early effects on glucose metabolism after surgery.