S
Skye Zeller
Researcher at Harvard University
Publications - 4
Citations - 309
Skye Zeller is an academic researcher from Harvard University. The author has contributed to research in topics: Alkaline phosphatase & Phosphorylation. The author has an hindex of 3, co-authored 4 publications receiving 268 citations.
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Journal ArticleDOI
Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
Madhu S. Malo,S Nasrin Alam,Golam Mostafa,Skye Zeller,Paul V. Johnson,N Mohammad,Kathryn T. Chen,Angela K. Moss,Sundaram Ramasamy,A Faruqui,S Hodin,P S Malo,Farzad Ebrahimi,Brishti Biswas,Sonoko Narisawa,José Luis Millán,H S Warren,Jeffrey B. Kaplan,Christopher L. Kitts,Elizabeth L. Hohmann,Richard A. Hodin +20 more
TL;DR: Oral supplementation of IAP favoured the growth of commensal bacteria, enhanced restoration of gut microbiota lost due to antibiotic treatment and inhibited the grow of a pathogenic bacterium (Salmonella typhimurium).
Journal ArticleDOI
Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase.
Kathryn T. Chen,Kathryn T. Chen,Madhu S. Malo,Angela K. Moss,Skye Zeller,Paul V. Johnson,Farzad Ebrahimi,Golam Mostafa,Sayeda Nasrin Alam,Sundaram Ramasamy,H. Shaw Warren,Elizabeth L. Hohmann,Richard A. Hodin +12 more
TL;DR: The mechanism of IAP action appears to be through dephosphorylation of specific bacterial components, including LPS, CpG DNA, and flagellin, and not on live bacteria themselves, and IAP likely targets these bacterially derived molecules in its role as a gut mucosal defense factor.
Journal ArticleDOI
Attenuated Listeria monocytogenes vaccine vectors expressing influenza A nucleoprotein: preclinical evaluation and oral inoculation of volunteers.
TL;DR: Comparison with prior work suggests that foreign antigen expression, and perhaps also freezing, may adversely affect the organisms’ immunogenicity.